DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14856 and slc22a7b.3

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_001337264.3	Gene:	slc22a7b.3 / 100001772	ZFINID:	ZDB-GENE-131120-103	Length:	546	Species:	Danio rerio

Alignment Length:	547	Identity:	133/547 - (24%)
Similarity:	243/547 - (44%)	Gaps:	48/547 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLE------NRSY 61
            |.|::::.:.....|:|.|:|.:..:..||:..|:...|.|..:|.|.|....|:      |.:.
Zfish     1 MKFEDLITEINGFGRFQKMILCISFVGRFIIPCHFLLSNFIAAIPSHHCDISFLDADGLFGNLTE 65

  Fly    62 AEIAAIYAP------------FKRPSCTRLASINMDGSNATASSEPCNRWIYHYDHG-FISMNAD 113
            .|...:..|            |..|....|  ||...|:.....|..|.|  |:|:. |||..|
Zfish    66 EERLIVSVPTQEDGSPVSCHMFSHPQFQLL--INSSSSSDLPVVECQNGW--HFDNSTFISTLA- 125

  Fly   114 LNW--VCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLL 176
            ..|  |||:....:...::||||.|.|...||.:.||.||...::::...|.....|::|:.:..
Zfish   126 TQWDLVCDNRGLNKAVATIFFVGVMFGAAFFGGMSDRFGRKPMLLVSYISGMAFALASVFSTSFT 190

  Fly   177 TFSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSF 241
            .|:..||.||........:..:|.||:|....|.: :::...:.:.:|....:....::..||..
Zfish   191 MFAVLRFFSGFTITGIVIVSSVLNLEWVDIEHRRL-VSIIDSMAWAVGSTSLALIAYFIRDWRWL 254

  Fly   242 MVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRR-DVSEADYELFRQHCKTK 305
            .|....|.:|.|..::.:.|||:||:...|.:.|...|.:.|..||: :|:.          :.|
Zfish   255 TVAVTSPLVLCTILWWWVPESARWLIANGDVEKAHYYLHKCAVMNRKAEVTS----------RIK 309

  Fly   306 ESEARSQMSMQ--KQARLIDSFKLPRLR-LRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFS 367
            .......:|.|  |:...:|..:.|::| |.::..||.|.:.|:.|. :|.|:.|..::.::...
Zfish   310 PEALAISVSDQGKKKYTYLDLVRTPKMRKLAMLTGTVWFCVATMTYG-ISLNITGFGLNMYLTQF 373

  Fly   368 LFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFG 432
            ::.....||.:....:.:..||:.|...:....|:     .:::..:......:...::.:...|
Zfish   374 VYGAIEVPSKLIVYYLLEKIGRRKTEAGAQLFAGI-----SLMINIFIPKDQWIGRTVVAVLGKG 433

  Fly   433 ISVTTGSTMQI-STELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVS 496
            .:|....|:.: |:||.||.:|.:|:......|.....::|.:|.|||::...|..|.|.:.|::
Zfish   434 FAVAAFCTIVLYSSELYPTVLRQNGMGYNSFLARLGVSVAPLVLLLDTFWGQFSQTILCSVALIA 498

  Fly   497 AWICLLLSETRNKKLPLTLAEGEEFGK 523
            :.:...|.|||::.||.|:.:.|..||
Zfish   499 SVVAWNLPETRDRCLPETIEDVEGTGK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	127/526 (24%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	86/378 (23%)
slc22a7b.3	XP_001337264.3	2A0119	12..516	CDD:273328	127/525 (24%)
slc22a7b.3	XP_001337264.3	MFS	141..506	CDD:119392	86/381 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950