DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and SLC22A13

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	566	Identity:	146/566 - (25%)
Similarity:	247/566 - (43%)	Gaps:	76/566 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSF---AEIEK 64
            |.::||:.|:..|:|..||.|...|..:...::|:...:.....|.|....::|.:|   |..:.
Human     4 FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAEQL 68

  Fly    65 IYS-------------QFEKPSC-TRLEKIDEDGQNHTLSRERCNR-WIYKYDFGYKSMNTELNW 114
            :.|             .|..|.. ..|:.|.....|.|   :.|:. |.|. :....|:..|.|.
Human    69 VLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNET---QPCDMGWEYP-ENRLPSLKNEFNL 129

  Fly   115 VCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGF-LGDFSTIFAGSLTSFSI 178
            |||..:.....||:|..|.:.|||.||.|.||||| :|.|||....| |...:|.|..|...:..
Human   130 VCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGR-KATILAQLLLFTLIGLATAFVPSFELYMA 193

  Fly   179 SRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSF-YCLGLIGACWLAVWVGHWRIFLAC 242
            .||....|....|:....|:.|:|.||.|...:  ||... :.||.:....||....:||:....
Human   194 LRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAV--VLAQCNFSLGQMVLAGLAYGFRNWRLLQIT 256

  Fly   243 SSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRKD 307
            .:.|.||:..:::.:.|||:||:||..:|.||:.:::.|.:|||:::.:       ...|...:.
Human   257 GTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPE-------LMNQLVPEK 314

  Fly   308 KNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSG 372
            .....:|  ||:.:.|::|.....:..::.:....|..::..|...|:..::...:......|:.
Human   315 TGPSGNA--LDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPAR 377

  Fly   373 YLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNV----LLLVG-LTMAARFGVSIAD 432
            .....:..|.|||.:.:|.:.:.|:..:   ::|...::..|    |.:|| :..||.|.:|..
Human   378 CSSIFMMQRFGRKWSQLGTLVLGGLMCI---IIIFIPADLPVVVTMLAVVGKMATAAAFTISYV- 438

  Fly   433 GASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYVCLL 497
                 :|.||.||.:|..|:.:|.:.......|:|.::.||.|:...|.:|.|.|.:....:|.|
Human   439 -----YSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTL 498

  Fly   498 LPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSKSEVEMGP 543
            ||||                .|:|:.|.|:          ::|:||
Human   499 LPET----------------HGQGLKDTLQ----------DLELGP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	136/520 (26%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	102/378 (27%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	138/538 (26%)
		MFS	139..500	CDD:119392	103/381 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153606
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950