DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and SLC22A8

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001171661.1	Gene:	SLC22A8 / 9376	HGNCID:	10972	Length:	542	Species:	Homo sapiens

Alignment Length:	570	Identity:	145/570 - (25%)
Similarity:	234/570 - (41%)	Gaps:	76/570 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIEKI 65
            |.|.|||.:.|:...:||:.:|:.|..::.::.|...|...:..|.|.|  ....|.|.......
Human     1 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHC--RPPHNASTGPWVLP 63

  Fly    66 YSQFEKPS-CTRL-----EKIDEDGQNHTLSRERC-NRWIYKYDFGYKSMNTELNWVCDEAYKAR 123
            .....||. |.|.     ..:..|.|.   :.|.| :.|:  |:....|:.||.:.||:......
Human    64 MGPNGKPERCLRFVHPPNASLPNDTQR---AMEPCLDGWV--YNSTKDSIVTEWDLVCNSNKLKE 123

  Fly   124 VGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFL----GDFSTIFAGSLTSFSISRFISG 184
            :.||:|..|.:.|.|..|.|.||.|| |.::.   |.:|    ......|:.:...:.:.||:.|
Human   124 MAQSIFMAGILIGGLVLGDLSDRFGR-RPILT---CSYLLLAASGSGAAFSPTFPIYMVFRFLCG 184

  Fly   185 LAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSSVPLLL 249
            ......:....||.:|:|...:|.: ::|.||..|..|......||..:..||......|:|..:
Human   185 FGISGITLSTVILNVEWVPTRMRAI-MSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFV 248

  Fly   250 VTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKIN-RRQVADK-DFKDFRIYCEQHYRKDKNQEE 312
            ..|..:...||.:|||.......|::.|.|||..| :::..:: ..::.::..::.....|
Human   249 FFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAK---- 309

  Fly   313 HAKLL--DMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSGYLQ 375
             ||..  |:.:.|.:|...|.|.|.:......|.::|..||..|::.:|:..:......|:.::.
Human   310 -AKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFIT 373

  Fly   376 GLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGL--------TMAARFGVSIAD 432
            .|....:||..|.            ||.|:::.|:   :|.|..:        |:.|.||...
Human   374 ILSLSYLGRHTTQ------------AAALLLAGGA---ILALTFVPLDLQTVRTVLAVFGKGC-- 421

  Fly   433 GASSQFS------TELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSG 491
             .||.||      :||.||.:|..|:.|.::.....|.:||.:...|......|:||.|:..|.|
Human   422 -LSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLG 485

  Fly   492 AYVCLLLPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSKSEVEM 541
            ....|.||||.|:.||            |.|.|......|.:..|.|.|:
Human   486 GSAALFLPETLNQPLP------------ETIEDLENWSLRAKKPKQEPEV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	131/524 (25%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	98/393 (25%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	133/538 (25%)
		MFS	96..493	CDD:119392	106/426 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..542		3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950