Protein Alignment CG14855 and SLC22A6

DIOPT Version :10

• Sequence 1: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_004781.2
• Gene: SLC22A6 / 9356
• HGNCID: 10970
• Length: 563
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 140/540 - (25%)
• Similarity: 242/540 - (44%)
• Gaps: 46/540 - (8%)

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIEKI 65
            |.|.::|.:.|...|:|.:.:.|....:::::.|...||..:.:|.|.|......|.|.....::
Human     1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEV 65

  Fly    66 Y----SQFEKPSCTR-------LEKIDEDGQNHTLSRERC-NRWIYKYDFGYKSMNTELNWVCDE 118
            :    .|.:..||.|       |..::....|.|.:.|.| :.|||.......::.||.:.||..
Human    66 WLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSH 130

  Fly   119 AYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSIS---- 179
            ....::.|||:.||.:.|.:.||.|.||:||.:.||| |:      ..|..:|:..:|:.:
Human   131 RALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLIL-NY------LQTAVSGTCAAFAPNFPIY 188

  Fly   180 ---RFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLA 241
               |.:||:|....|.....|.:|:: |......:.|::|..|.||......:|..|.|||....
Human   189 CAFRLLSGMALAGISLNCMTLNVEWM-PIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQL 252

  Fly   242 CSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKIN--RRQVADKDFKDFRIYCEQHY 304
            ..|.|.....::.:...|||:|..:...:|..:|.|:|||:||  |.:.|....:..|...::..
Human   253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKEL 317

  Fly   305 RKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPF-IMFSLNALTL 368
            ...|.|   |..:::|:.|.:|.....|.:::......|..:..:::|.|:|.: |.....|:.|
Human   318 TMGKGQ---ASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDL 379

  Fly   369 PPSGYLQG-LLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSN--RNVLLLVGL-TMAARFGVS 429
            |..  |.| |:.:.:||:...:..:.:.||..:..| ||.|..:  |..|.::|. .:||.|...
Human   380 PAK--LVGFLVINSLGRRPAQMAALLLAGICILLNG-VIPQDQSIVRTSLAVLGKGCLAASFNCI 441

  Fly   430 IADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYV 494
            ..      ::.||.||.:|..|:.:........|.:||.:......|...|..|.|.:.::.:.|
Human   442 FL------YTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAV 500

  Fly   495 CLLLPETRNKKLPMSLAEGE 514
            .:|||||..:.||.::.:.|
Human   501 TVLLPETLGQPLPDTVQDLE 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	134/521 (26%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	136/523 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..563