Protein Alignment CG14855 and Sv2c

DIOPT Version :10

• Sequence 1: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_083486.1
• Gene: Sv2c / 75209
• MGIID: 1922459
• Length: 727
• Species: Mus musculus
• Alignment Length: 683
• Identity: 115/683 - (16%)
• Similarity: 200/683 - (29%)
• Gaps: 293/683 - (42%)

  Fly    46 DHWCYHEQLENRSFAEIEKIYSQFEKPSCTRLEKIDEDGQNHTLSRERCN----RW--------- 97
            |.:....:||:...|:.|::..|:|                  |..:.|.    :|
Mouse   115 DEYKDRRELESERRADEEELAQQYE------------------LIIQECGHGRFQWALFFVLGMA 161

  Fly    98 -------IYKYDFGYKSMNTEL-------NWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIG 148
                   ::...|...|..|:|       .|:          .|:.::|.:.|...:|.|.|::|
Mouse   162 LMADGVEVFVVGFVLPSAETDLCIPNSGSGWL----------GSIVYLGMMVGAFFWGGLADKVG 216

  Fly   149 RIRALILANWC----GFLGDFSTIFAGSLTSFSISRFISGLAADAN-----SYLMYILILEYVSP 204
            |.::|::   |    ||.. |.:.|......|.:.|.:||......     ||...:|..|....
Mouse   217 RKQSLLI---CMSVNGFFA-FLSSFVQGYGFFLVCRLLSGFGIGGAIPTVFSYFAEVLAREKRGE 277

  Fly   205 SLRNVGLNTVLGSFYCLGLIGACWLAV----W---VG------HWRIFLACSSVPLLLVTLFYFL 256
            .|..:.:..::|..|...:   .|..:    |   :|      .||:|:...::|.:...:....
Mouse   278 HLSWLCMFWMIGGIYASAM---AWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTF 339

  Fly   257 VQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRKDKNQEEHAKLLDMLK 321
            :.||.::|:.....|.|...|:.:...|.|.                    :.|.|....::.:|
Mouse   340 MPESPRFLLEVGKHDEAWMILKLIHDTNMRA--------------------RGQPEKVFTVNKIK 384

  Fly   322 TP----------------------RMRSTAFKLLLIFIIIVPCYN-------------------- 344
            ||                      |:|:..:.:.|.|   :.|:|
Mouse   385 TPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTF---MRCFNYPVRENTIKLTIVWFTLSFG 446

  Fly   345 ---------------------TIARNVEG---------------------------LGI------ 355
                                 .:.|||:.                           ||:
Mouse   447 YYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQIHTGMEYENGRFLGVKFKSVT 511

  Fly   356 ------------------------------------SP--------------------------- 357
                                                .|
Mouse   512 FKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDD 576

  Fly   358 -------FIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGI------FAVAAGLVISQG 409
                   |:.| |..|.:.|...:..||.||:||.....|.|.::||      |..:..::|..
Mouse   577 YSAYWIYFVNF-LGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGM- 639

  Fly   410 SNRNVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYIL-HLG 473
                :.|..|||::|...:.:.       :.||.||..|..|...::....||:.|...|. .|.
Mouse   640 ----LCLYNGLTISAWNSLDVV-------TVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLV 693

  Fly   474 TYYKPAPSIILGLLFLSGAYVCLLLPETRNKKL 506
            :..|..|.::...:.:.|..|.|.||:||.:.|
Mouse   694 SITKAIPILLASTVLVCGGLVGLRLPDTRTQVL 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	115/683 (17%)
Sv2c	NP_083486.1	synapt_SV2	1..727	CDD:130366	115/683 (17%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..128		3/12 (25%)