DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and LOC685081

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_008764922.2	Gene:	LOC685081 / 685081	RGDID:	1583222	Length:	621	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	133/574 - (23%)
Similarity:	246/574 - (42%)	Gaps:	50/574 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSF--AEIEKI 65
            |.:::|:.|:...:|..:..|.|....:.:...|||..:.....|.|....::|.:|  :..|::
  Rat     4 FAQVMAEVGDFGPFQVRVTILMGIPNFLSAFFVFSQVFMVLDEAHHCSVSWVKNHTFNLSAAEQL 68

  Fly    66 YSQFEK---------------PSCTRLEKIDEDGQNHTLSRERCNR-WIYKYDFGYKSMNTELNW 114
            ......               |....||.|.....|.|   :.|:. |.|. :....|:..|.:.
  Rat    69 AVSIPNDTAGRPESCLMFRPPPDSASLEDILSHRFNET---QACDSGWDYP-ENRPPSLKNEFDL 129

  Fly   115 VCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSIS 179
            ||:.....|..||:|..|.:.|.|.||.:.|.|||..:::|......:...:|.|..|...:.:.
  Rat   130 VCERENLKRTSQSVFMAGLLVGALVFGPVCDWIGRRASILLQVLLSGITGVATAFVPSFELYMVL 194

  Fly   180 RFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSS 244
            .|.|.:|.........||:.|:|.||.|...: .:..|.:.|||:....||..|.:||:.....:
  Rat   195 CFFSAIAVAGYMMSTMILVSEWVGPSWRTRAM-VLAQSNFALGLMALAGLAYGVRNWRLLQIIGT 258

  Fly   245 VPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRKDKN 309
            .|:.|:..:::::.||.:||:::...:.|.:.:::.|.:|.|.:|.:       ...|...:...
  Rat   259 TPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLASE-------LLNQLVPEKTG 316

  Fly   310 QEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSGYL 374
            ...:|  ||:.:.|::|.....|:.::.:....|..:...|...|:..::...:..:...|:...
  Rat   317 PSGNA--LDLFRHPQLRKVTLILIAVWFVDSLLYYGLGFQVGDFGLDIYLTQVIFGVVEVPARLS 379

  Fly   375 QGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTMAARFGVSIADGASSQFS 439
            ...:.:::|||.:.:..:.:.|:..|.  ::...|....|  ...|.:..:|..|.|...|..::
  Rat   380 SIPMMEKLGRKWSQLCTLTLAGVMCVI--IIFIPGDLPTV--ATALAVVGKFASSAAFTISYVYT 440

  Fly   440 TELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYVCLLLPETRNK 504
            .||:||.:|..|:.:|.:.......::|.::.|..|:|..|.:|.|.|.:....:|.||||||.:
  Rat   441 AELLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPMLIFGSLPIGAGLLCALLPETRGQ 505

  Fly   505 KLPMSLAEGEEFG-RGEGIFDFLRHMFRREGSKSE----VEMGPTIVEEDTLIN 553
            .|..:|.:.|:.| .||         .|..|...:    |.:||.:|....|.|
  Rat   506 TLKDTLQDLEQGGPHGE---------HRLLGLSLDPGLPVTIGPLLVNPCLLSN 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	117/513 (23%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	85/371 (23%)
LOC685081	XP_008764922.2	2A0119	12..510	CDD:273328	118/515 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950