Protein Alignment CG14855 and SLC22A5

DIOPT Version :9

• Sequence 1: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 151/606 - (24%)
• Similarity: 245/606 - (40%)
• Gaps: 91/606 - (15%)

  Fly     2 DFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIE--- 63
            |::|:.|..|....:|.::..|....::.......|...:...|:|.|......|.|.|...
Human     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTV 67

  Fly    64 --KIYSQFEKP-SCT--RLEKI------------DED-GQNHTLSRERC-NRWIYKYDF------ 103
              ::....|.| ||.  ||..|            |.| ||   |.:|.| :.|.:..|.
Human    68 PLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQ---LEQESCLDGWEFSQDVYLSTIV 129

  Fly   104 ------GYKSMNTEL------------NWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRI 150
                  .|.:|...:            |.||::.:||.:..||||||.:.|:...|.|.||.||.
Human   130 TEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRK 194

  Fly   151 RALI--LANWCGFLGDFSTIFAGSLTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNT 213
            ..|.  :....||  .|..||:.:...|.:...:.|:...:|....::|..|.:..|:|.:....
Human   195 NVLFVTMGMQTGF--SFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTL 257

  Fly   214 VLGSFYCLGLIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLE 278
            .:..||..|.:.....|.::..||:.|...::|.:|....::.:.||.:||:::...:.|...:.
Human   258 GVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIR 322

  Fly   279 RVAKINRRQVADKDFKDFRIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCY 343
            :.||.|...|....|..    .|......|.|:.| .:||:|:|..:|......:::::.|...|
Human   323 KAAKANGIVVPSTIFDP----SELQDLSSKKQQSH-NILDLLRTWNIRMVTIMSIMLWMTISVGY 382

  Fly   344 NTIARNVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQ 408
            ..::.:...|....|:...|:|:...|:..|..||...:.|:     :...|.:|...:.|:..|
Human   383 FGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRR-----YSMATALFLGGSVLLFMQ 442

  Fly   409 GSNRNVLLLVG-LTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHL 472
            ....::..|.. |.|..:|||:.|......::.||.||.||..||.|...|....|.||||.::|
Human   443 LVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 507

  Fly   473 GTYYKPAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSK- 536
            |.|.:..|.|::|.|.:..|.:.|.|||:....||                |.:..|.|.:|.|
Human   508 GAYDRFLPYILMGSLTILTAILTLFLPESFGTPLP----------------DTIDQMLRVKGMKH 556

  Fly   537 ----SEVEM------GPTIVE 547
                |...|      .|||::
Human   557 RKTPSHTRMLKDGQERPTILK 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	136/544 (25%)
		MFS	127..499	CDD:119392	100/374 (27%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	138/562 (25%)
		MFS	162..534	CDD:119392	102/383 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153718
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950