Protein Alignment CG14855 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 136/579 - (23%)
• Similarity: 237/579 - (40%)
• Gaps: 110/579 - (18%)

  Fly     3 FEEILAKCGNSSRYQ---FVLLALYGYLMVVVSMHYFSQNVISFVPDH-WCYHEQLENRSFAEIE 63
            |:|.|.:.|...|:|   |:||.|.|   |..:..:.....:...||| ||
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTG---VTFAFLFVGVVFLGTQPDHYWC-------------- 51

  Fly    64 KIYSQFEKPSCTRLEK----IDEDGQNHTL----------SRERCNRWI---------------- 98
                  ..||...|.:    ..|:..|.|.          .|.||.|::
Human    52 ------RGPSAAALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSC 110

  Fly    99 --------------------YKYDFGYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLL 143
                                ::|...:.::.:|.:.||..|:...:.|::..:|.:.|....|..
Human   111 ADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYA 175

  Fly   144 GDRIGRIRALILANWCGFLGDFSTI--FAGSLTSFSISRFISGLAADANSYLMYILILEYVSPSL 206
            .||.|||...:|:  |..:|....:  ||.:...|.|.||:.|:.........|:::.|.|....
Human   176 ADRYGRIVIYLLS--CLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQ 238

  Fly   207 RNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVD 271
            |.: :..|:..|:.||:|....:|.::.:|:......::|..|..|:|::|.||.:||:||...|
Human   239 RRI-VGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGD 302

  Fly   272 GAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRKDKNQEE---HAKLLDMLKTPRMRSTAFKLL 333
            .|::.|.|:||.|.:            |...:|.:....:|   :...||:::||:||.....|:
Human   303 KALQILRRIAKCNGK------------YLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILM 355

  Fly   334 LIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIF 398
            ..:......|..:...:..:|.:.:|.|.::.:...|...|..|..:|:||:..    .|.:.|.
Human   356 FAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLP----FAASNIV 416

  Fly   399 AVAAGLVISQGSNRNVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAAS 463
            |..|.||.:........|...:....|.|:::|.......::||.||::|..||::.........
Human   417 AGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGG 481

  Fly   464 FLSPYIL-HLGTYYKPAPSIILGLLFLSGAYVC----LLLPETRNKKLPMSLAEGEEFG 517
            .::|::| .|...:...|.||.|:|    |.:|    :|||||:...||.::.:.|:.|
Human   482 IIAPFLLFRLAAVWLELPLIIFGIL----ASICGGLVMLLPETKGIALPETVDDVEKLG 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	129/559 (23%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	131/561 (23%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		2/3 (67%)