Protein Alignment CG14855 and SLC22A1

DIOPT Version :9

• Sequence 1: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 135/531 - (25%)
• Similarity: 231/531 - (43%)
• Gaps: 88/531 - (16%)

  Fly     4 EEILAKCGNSSRYQ---FVLLALY--GYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIE 63
            ::||.:.|.|..:|   |::|.|.  .:..:.|.:.:     :.|.|||.|     ::...||:.
Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVF-----LGFTPDHHC-----QSPGVAELS 59

  Fly    64 KI--YSQFEKPSCT-------------RLEKIDEDGQNHTLSRERC---------NR-------- 96
            :.  :|..|:.:.|             :..:.:.|.....||   |         ||
Human    60 QRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALS---CVDPLASLATNRSHLPLGPC 121

  Fly    97 ---WIYKYDFGYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGR---IRALIL 155
               |:  ||....|:.||.|.||.:::|..:.||....|.:.|:|..|...||.||   :...:|
Human   122 QDGWV--YDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVL 184

  Fly   156 AN-WCGFLGDFSTIFAGSLTSFSISRFISGLAADANSYLMYILILEYV-SPSLRNVGLNTVLGSF 218
            .| ..|.|..||..:...|    :.|.:.||.:..|....|.||.|:| |.|.|.|.:...:.
Human   185 VNAVSGVLMAFSPNYMSML----LFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMA-- 243

  Fly   219 YCLGLIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKI 283
            :.:||:....||..:.|||......|:|..|..|:|:.|.||.:||:::.....||:.::.:|:.
Human   244 FTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQK 308

  Fly   284 NRRQVADKDFKDFRIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIAR 348
            |.: :...|.|...:      .:|..::......|:.:|||:|...|.|:.::......|..:..
Human   309 NGK-LPPADLKMLSL------EEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLIL 366

  Fly   349 NVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLV---ISQGS 410
            ::.....:.::.|..:||...|..::..:..||:||    :..||::.:.|.||.||   ||...
Human   367 HMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGR----IYPMAMSNLLAGAACLVMIFISPDL 427

  Fly   411 N-RNVLLL-VGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYIL-HL 472
            : .|:::: ||     |.|::||.......:.||.||.||..||.|..........::|:|: .|
Human   428 HWLNIIIMCVG-----RMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRL 487

  Fly   473 GTYYKPAPSII 483
            ...::..|.|:
Human   488 REVWQALPLIL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	133/524 (25%)
		MFS	127..499	CDD:119392	99/368 (27%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	133/524 (25%)
		MFS	118..484	CDD:119392	106/389 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950