DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_071606.1	Gene:	Slc22a4 / 64037	RGDID:	621149	Length:	553	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	146/570 - (25%)
Similarity:	254/570 - (44%)	Gaps:	62/570 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFA------ 60
            |::|::|..|:...:|.::..|....::....:..|...::..|:|.|......|.|.|
  Rat     3 DYDEVIAFLGDWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPHTVNLSSAWRNHSI 67

  Fly    61 EIEKIYSQFEKPSCTR-------------LEK-IDEDGQNHTLSRERC-NRWIYKYDFGYKSMNT 110
            .:|....:....||.|             ||. :|.|.:.  |.:|.| :.|.|..|....::.|
  Rat    68 PLETKDGRQVPQSCRRYRLATIANFSALGLEPGLDVDLEQ--LEQESCLDGWEYSKDVFLSTIVT 130

  Fly   111 ELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALI--LANWCGFLGDFSTIFAGSL 173
            |.|.||::.:|..:..||||||.:||:...|.|.||.||.:.|.  :|...||  .|..||:.:.
  Rat   131 EWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGF--SFVQIFSTNW 193

  Fly   174 TSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLG--SFYCLGLIGACWLAVWVGHW 236
            ..|::...|.|:...:|..:.:||..|.:|.|:|.  |.:.||  :|:.:|.:.....|.::..|
  Rat   194 EMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRI--LFSTLGVCTFFAIGYMVLPLFAYFIRDW 256

  Fly   237 RIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCE 301
            |:.|...::|.|.....::.:.||.:||:::...:.|.:.:::.||:|........|....:
  Rat   257 RMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFEEAEQIIQKAAKMNGIMAPAVIFDPLEL--- 318

  Fly   302 QHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNAL 366
            |.....|.|:  ..:||:.||..:.:.....::::::....|..::.||..|....::...|:.|
  Rat   319 QELNSLKQQK--VFILDLFKTRNIATITVMSVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSGL 381

  Fly   367 TLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGL-----VISQGSNRNVLLLVGLTMAARF 426
            ...|:.:...||...:.|:      ..|.|:.....|:     |:.:..|   .:.:||.|..:|
  Rat   382 IEVPAYFTAWLLLRTLPRR------YIIAGVLFWGGGVLLLVQVVPEDYN---FVSIGLVMLGKF 437

  Fly   427 GVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSG 491
            ||:.|......|:.||.||.||...|.:..:|....|.::||.::||.|.:..|.|::|.|.:..
  Rat   438 GVTSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLI 502

  Fly   492 AYVCLLLPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSKSEVEM 541
            ..:.|..||:....||.:|   |:..:..|.         |.|.||.|.|
  Rat   503 GIITLFFPESFGVTLPENL---EQMQKVRGF---------RCGKKSTVSM 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	132/525 (25%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	100/380 (26%)
Slc22a4	NP_071606.1	2A0119	12..519	CDD:273328	133/526 (25%)
Slc22a4	NP_071606.1	MFS	123..510	CDD:119392	106/404 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020