Protein Alignment CG14855 and SLC22A23

DIOPT Version :9

• Sequence 1: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_011513103.1
• Gene: SLC22A23 / 63027
• HGNCID: 21106
• Length: 710
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 134/624 - (21%)
• Similarity: 216/624 - (34%)
• Gaps: 167/624 - (26%)

  Fly    11 GNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCY------------------------- 50
            |....||..|:.|.....:.:....||.:.:...|:.||.
Human    90 GLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTS 154

  Fly    51 ----------HEQLENRSFAEIEKIYSQFEKPSCTRLEKIDEDGQNHTLSRERCNRWIY------ 99
                      .|...|||.:      |..:......|....:.|.|  .|...|..|.|
Human   155 LPTTPFATAPWEAAGNRSNS------SGADGGDTPPLPSPPDKGDN--ASNCDCRAWDYGIRAGL 211

  Fly   100 -----------------KYDFGYKSMNTELNW--VCDEAYKARVGQSLFFVGSVCGTLAFGLLGD 145
                             .:|...|....||||  |||.|:|..:.:....||.:.|.|..|.:.|
Human   212 VQNVVSKCCQQQETGALPWDTDTKRWRPELNWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIAD 276

  Fly   146 RIGRIRALILANWCGFLGDFSTIF----------AGSLTSFSISRFISGLAADANSYLMYILILE 200
            .:|| |.::|         ||.||          :.::|.||..||..|.........:|.|.:|
Human   277 WVGR-RPVLL---------FSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIE 331

  Fly   201 YVSPSLRNVGLNTVLGSFYCL-------GLIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQ 258
            ...|..|  .:.|::.||..:       ||...|      ..|::..|....|.||:.|::.:..
Human   332 LCPPGKR--FMITMVASFVAMAGQFLMPGLAALC------RDWQVLQALIICPFLLMLLYWSIFP 388

  Fly   259 ESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRKDKNQEEHAKLLDMLKTP 323
            ||.:||:.....:.|.|.:....:.||.. .:.|.|......|      |......|.:.::|..
Human   389 ESLRWLMATQQFESAKRLILHFTQKNRMN-PEGDIKGVIPELE------KELSRRPKKVCIVKVV 446

  Fly   324 RMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSL--NALTLPPSGYLQGLLQDR----- 381
            ..|:      |...|:|.|.|::.    |.||......|:  :.:.:|   .|:....|.
Human   447 GTRN------LWKNIVVLCVNSLT----GYGIHHCFARSMMGHEVKVP---LLENFYADYYTTAS 498

  Fly   382 ---------------MGRKATAVGWMAITGIFA-VAAGLV-----ISQ----GSNRNV--LLLVG 419
                           :||:...:.:|.:|.:.: :..||:     .||    |.:.:|  ...:.
Human   499 IALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIA 563

  Fly   420 LTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYI-LHLGTYYKPAPSII 483
            .::...|........|..|..|:.||.:|..|:.:|..:.......:|.| ||....|     .:
Human   564 FSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGY-----FL 623

  Fly   484 LGLLFLSGAYVC----LLLPETRNKKLPMSLAEGEEFGR 518
            ..::|.....:|    |||||:|::.||.:::.||.:.|
Human   624 HHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTR 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	129/611 (21%)
		MFS	127..499	CDD:119392	92/427 (22%)
SLC22A23	XP_011513103.1	2A0119	<243..652	CDD:273328	103/451 (23%)
		MFS	259..>388	CDD:119392	37/146 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153279
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.030