Protein Alignment CG14855 and SLC22A23

DIOPT Version :10

• Sequence 1: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_054212174.1
• Gene: SLC22A23 / 63027
• HGNCID: 21106
• Length: 718
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 137/632 - (21%)
• Similarity: 219/632 - (34%)
• Gaps: 175/632 - (27%)

  Fly    11 GNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCY------------------------- 50
            |....||..|:.|.....:.:....||.:.:...|:.||.
Human    90 GLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTS 154

  Fly    51 ----------HEQLENRSFAEIEKIYSQFEKPSCTRLEKIDEDGQNHTLSRERCNRWIY------ 99
                      .|...|||.:      |..:......|....:.|.|  .|...|..|.|
Human   155 LPTTPFATAPWEAAGNRSNS------SGADGGDTPPLPSPPDKGDN--ASNCDCRAWDYGIRAGL 211

  Fly   100 -----------------KYDFGYKSMNTELNW--VCDEAYKARVGQSLFFVGSVCGTLAFGLLGD 145
                             .:|...|....||||  |||.|:|..:.:....||.:.|.|..|.:.|
Human   212 VQNVVSKCCQQQETGALPWDTDTKCWRPELNWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIAD 276

  Fly   146 RIGRIRALILANWCGFLGDFSTIF----------AGSLTSFSISRFISGLAADANSYLMYILILE 200
            .:|| |.::|         ||.||          :.::|.||..||..|.........:|.|.:|
Human   277 WVGR-RPVLL---------FSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIE 331

  Fly   201 YVSPSLRNVGLNTVLGSFYCL-------GLIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQ 258
            ...|..|  .:.|::.||..:       ||...|      ..|::..|....|.||:.|::.:..
Human   332 LCPPGKR--FMITMVASFVAMAGQFLMPGLAALC------RDWQVLQALIICPFLLMLLYWSIFP 388

  Fly   259 ESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRKDKNQEEHAKLLDMLKTP 323
            ||.:||:.....:.|.|.:....:.||.. .:.|.|......|      |......|.:.::|..
Human   389 ESLRWLMATQQFESAKRLILHFTQKNRMN-PEGDIKGVIPELE------KELSRRPKKVCIVKVV 446

  Fly   324 RMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSL--NALTLPPSGYLQGLLQDR----- 381
            ..|:      |...|:|.|.|::.    |.||......|:  :.:.:|   .|:....|.
Human   447 GTRN------LWKNIVVLCVNSLT----GYGIHHCFARSMMGHEVKVP---LLENFYADYYTTAS 498

  Fly   382 ---------------MGRKATAVGWMAITGIFA-VAAGLVISQG-------SNRNVLLLVGLTMA 423
                           :||:...:.:|.:|.:.: :..||:...|       |...:.|.||::.:
Human   499 IALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSELQLKLAVGMSDS 563

  Fly   424 ARFGVSIA------------DGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYI-LHLGTY 475
            .:...|||            ...|..|..|:.||.:|..|:.:|..:.......:|.| ||....
Human   564 VKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKG 628

  Fly   476 YKPAPSIILGLLFLSGAYVC----LLLPETRNKKLPMSLAEGEEFGR 518
            |     .:..::|.....:|    |||||:|::.||.:::.||.:.|
Human   629 Y-----FLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTR 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	132/619 (21%)
SLC22A23	XP_054212174.1	MFS_SLC22A23	192..637	CDD:341002	108/489 (22%)