DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	571	Identity:	134/571 - (23%)
Similarity:	245/571 - (42%)	Gaps:	58/571 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDH-------------WCYHE 52
            :|::|:.|..|....:|.::..|....::.......|...::.:|:|             |..|.
Mouse     2 LDYDEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIPEHRCRIPDTVNLSSAWRNHS 66

  Fly    53 -QLENRSFAEIEKIYSQFEKPSCTRLEKID-EDGQN---HTLSRERC-NRWIYKYDFGYKSMNTE 111
             .:|.:...|:.:...::...:.....::. |.|::   ..|.:|.| :.|.|..|....::.||
Mouse    67 IPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQENCLDGWEYDKDIFLSTIVTE 131

  Fly   112 LNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGR--IRALILANWCGFLGDFSTIFAGSLT 174
            .:.||.:.:||.:..|.|:||.:.|:...|.|.||.||  |..|.:|...||  .|..:|:.:..
Mouse   132 WDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLTMAMHTGF--SFIQVFSVNFE 194

  Fly   175 SFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIF 239
            .|::...:.|:...:|....::|..|.:|.|:|.:.....:..|:..|.:.....|.::..||..
Mouse   195 MFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLGVCIFFAFGFMVLPLFAYFIREWRRL 259

  Fly   240 LACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHY 304
            |...::|.:|....::.:.||.:||:::..:..|...:.:.||||........|........|..
Mouse   260 LLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSETNKLQDD 324

  Fly   305 RKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLP 369
            ...|.|..|  :.|:::||.:|......:::::.|...|..::.:...|..:.::...|.|....
Mouse   325 SSKKPQSHH--IYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEV 387

  Fly   370 PSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLV------------GLTM 422
            |:..|..||...:.|:.:..|.:.:.|                :|||||            .|.|
Mouse   388 PAYVLAWLLLQHVSRRYSMAGSLFLGG----------------SVLLLVQLVPSDLHYLSTTLVM 436

  Fly   423 AARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLL 487
            ..:||::.|......::.||.||.||..||.|...|....|.||||.::||.|.:..|.|::|.|
Mouse   437 VGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSL 501

  Fly   488 FLSGAYVCLLLPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSKSE 538
            .:..|.:.|..||:....||.::.|.::..:.:     .|....::||..|
Mouse   502 TILTAIITLFFPESSGVSLPETIDEMQKVKKLK-----QRQSLSKKGSPKE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	124/528 (23%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	98/385 (25%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	126/530 (24%)
		MFS	123..513	CDD:119392	104/409 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564		4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843878
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950