DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and slc22a16

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001020659.1	Gene:	slc22a16 / 557279	ZFINID:	ZDB-GENE-041001-166	Length:	565	Species:	Danio rerio

Alignment Length:	560	Identity:	137/560 - (24%)
Similarity:	238/560 - (42%)	Gaps:	67/560 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWC---------YHEQLENRSF 59
            |.:..:.|:..|:|..|.....:..:...:||.:...:...|...|         .::.|...|.
Zfish     6 ERLFDELGHFKRFQACLYFAAIFQAISCGIHYLASVFLVETPKFLCNPPLNITDVLYKNLSFTSL 70

  Fly    60 AEIEKIY--------------SQFEKPSCTRLEKIDEDGQNHTL----SRERCNRWIYKYDFGYK 106
            |:|...|              .|:|...|.:..::|.....:..    |.|.|..::|.:....:
Zfish    71 ADIWTHYKTGDGPVVVRTSQGDQWELSPCLKALRLDAINFQYEFFGNKSVESCGAFVYDHSEVEQ 135

  Fly   107 SMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAG 171
            |:.|:.:.||:..:.|::.|..|.:|.:.|.|.||...|||||...|:..:.|.|:...:..|.|
Zfish   136 SIVTDWDLVCEREWLAKLTQPTFMLGVLIGALMFGDAADRIGRRPVLMATSLCQFIFGVTVAFTG 200

  Fly   172 SLTSFSISRFISGLAADANSYL--MYILILEYVSPSLRN-----------VGLNTVLGSFYCLGL 223
            :...|.:.||:  ||..::.||  :::.:.|:....:|.           ||:..|.    .:|.
Zfish   201 NYYLFVVMRFL--LATVSSGYLVVVFVYVTEFTGIKVRTWTSMHVHAAFAVGIMVVA----LVGY 259

  Fly   224 IGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQV 288
            :...|   |:  ::|.|..|:.|.|   |:.:...|:..:|:.:.....|...|:.:|.||....
Zfish   260 LVRVW---WI--YQIILTLSTSPFL---LYCWKFPETPFYLMAKGRYKEAQELLDTMAYINGLPP 316

  Fly   289 ADKDFKDFRIYCEQHYRKDKNQ----EEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARN 349
            ..| ..|.:..|::...||..|    |:...:|||..:.:|...:.....|:.|....|...:..
Zfish   317 TLK-VSDLQDGCDRTPLKDNKQAMEVEKRLSMLDMFGSLKMAGRSATCWAIWFIGSLGYYVFSLG 380

  Fly   350 VEGLGISPFI-MFSLNALTLPPSGYLQG-LLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNR 412
            ...||.:.:| :|...|:.:|  .||.| ...||.|||.|....:.:.|   ||..|:|....:.
Zfish   381 SVNLGGNQYINLFLAGAVEVP--SYLIGCFAMDRFGRKKTCAPALLLGG---VACMLIIVVPQDV 440

  Fly   413 NVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYK 477
            .||.:| |:|..:|.::||.|....::.||.||.:|...|....:.....|.::|:.::|...:.
Zfish   441 EVLAIV-LSMTGKFAIAIAFGLIYLYTCELYPTIIRSLAVGSGSMMCRVGSVVAPFCVYLADIWI 504

  Fly   478 PAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFG 517
            ..|.:|:|:|......:.:.||||..:.|..:|.|.|..|
Zfish   505 YLPQLIVGILAFIIGILTMFLPETLGEPLTSTLEEAEALG 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	131/541 (24%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	100/390 (26%)
slc22a16	NP_001020659.1	2A0119	13..536	CDD:273328	132/543 (24%)
slc22a16	NP_001020659.1	MFS	158..526	CDD:119392	100/388 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588806
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850