DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Orct2

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	133/556 - (23%)
Similarity:	246/556 - (44%)	Gaps:	65/556 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWC-----------YHEQL 54
            |.::|.:...|:..|||.::..|.....:.|:.|..:...:...||..|           ....|
  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL 65

  Fly    55 ENRSFAEIEKIYSQFEKPSCTRLEKID--EDGQNHTLSR-----ERCNRWIYKYDFGYKSMNTEL 112
            .|.|:.|.|:         |:..: :|  |:..|.::.|     :.|:.::|.......|..||.
  Fly    66 WNLSYPENER---------CSYYD-VDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEW 120

  Fly   113 NWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGR----IRALILANWCGFLGDFSTIFAGSL 173
            |.||...:.|....|||.:|.:.|::.||.|.|:.||    ..:|::....|.|..    .|...
  Fly   121 NLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAG----VAPEY 181

  Fly   174 TSFSISRFISGLAADANSYLMYILILEYVSPSLR-NVGLNTVLGSFYCLGLIGACWLAVWVGHWR 237
            .:::.:|.:.|........:.|::.:|.|.|..| ..|:..::  |:.:|.:.....|.:|..||
  Fly   182 FTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMM--FFSVGFMLTAVFAYFVHDWR 244

  Fly   238 IFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQ 302
            ......::|.|:...:|:::.|||:||:.:...|.||..:::.|:.|:.:::|:...:.
  Fly   245 WLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSEL------ 303

  Fly   303 HYRKDKNQEEHAK---------------LLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEG 352
             ..:.:|.||.||               :.|:...|.:|.....:.|.:::....|..::.|...
  Fly   304 -LDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSN 367

  Fly   353 LGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLL 417
            ||.:..:.|.::.....|:.....|..:|.||::...|.:.:.|: ::.|.::|.|   |...|:
  Fly   368 LGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGL-SLLATVIIPQ---RMHTLI 428

  Fly   418 VGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSI 482
            |...|..:..::.:.|....||.|..||.||...:....:....:..::|::..|.|.:||.|.:
  Fly   429 VACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLL 493

  Fly   483 ILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGR 518
            |.|.|.|....:.||||||.||.:..::|:||.||:
  Fly   494 ICGSLTLVAGLLSLLLPETHNKPMLETIADGERFGK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	126/533 (24%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	91/391 (23%)
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	126/535 (24%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	90/392 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458390
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.990