DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and CG16727

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	247/553 - (44%)
Similarity:	345/553 - (62%)	Gaps:	24/553 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIEKI 65
            |||:.:|.||||..|:|||:|.||||..::.|:|||||.:|:|.|:|||.|:.|.....||:..|
  Fly     1 MDFDRVLEKCGNFGRFQFVILILYGYTNILSSLHYFSQTLITFTPEHWCSHDDLMGLGAAELRSI 65

  Fly    66 YSQFEKPSCTRL-EKIDEDGQNHTLSRERCNRWIYKYDFGYKSMNTELNWVCDEAYKARVGQSLF 129
            ||....||||.| |.|:..|   ..|.|.|..||::.:.||:|:.|||.||||::::..||||.|
  Fly    66 YSNVSHPSCTLLSEVINGTG---VASEESCQDWIFERENGYESLTTELKWVCDKSHQPAVGQSFF 127

  Fly   130 FVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSISRFISGLAADANSYLM 194
            |:|||.||::||.|.|.|||:.|:::|...|..|||.|.|..:|..|:.|||:|||:.|...|||
  Fly   128 FLGSVVGTISFGFLSDHIGRLPAMLMAALSGATGDFITSFVHTLPWFAFSRFVSGLSTDTMYYLM 192

  Fly   195 YILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQE 259
            |||:.||:||..|..|||.:|..|||.||:.:.|:|:|:|:||.:|..:|:|.|.|.::..|:.|
  Fly   193 YILVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNWRRYLWLASLPALGVLIYPLLICE 257

  Fly   260 SAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRKDKNQEEHAKL-------L 317
            |||||:|:...|.|:..|::|||.|.|||.|..|.:|    .:|||:..|:|  :||       |
  Fly   258 SAQWLLTKKKYDEAVACLKKVAKFNGRQVEDSVFDEF----VKHYREKMNEE--SKLNKQMDTFL 316

  Fly   318 DMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRM 382
            .|.||||:|.....||:..:||...|:.|.||:||||.|||.:|||.:....|:|:...|||:::
  Fly   317 GMFKTPRLRRFTTTLLVKSVIITLSYDVINRNMEGLGSSPFKLFSLTSSVYLPAGFTILLLQNKI 381

  Fly   383 GRKATAVGWMAITGIFAVAAGLVIS-QGSNRNVLLLVGLTMAARFGVSIADGASSQFSTELIPTS 446
            |||..|.|.:.:..|.....|.:|: ...:.|.:||..:....|||.:::..|..|::.|:||||
  Fly   382 GRKGMACGALLVGAIITAVTGFLIAVLDPSENAVLLALMVGLGRFGTTVSYDAEIQYAAEIIPTS 446

  Fly   447 VRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLA 511
            |||:.|:.:||.|.|:|.|:.|:::|..||||.|||.:.:|...||.:||.||||.:||||.:||
  Fly   447 VRGQAVSNIHVVGLASSSLAFYVIYLAQYYKPLPSIFISVLMFLGALLCLTLPETLHKKLPETLA 511

  Fly   512 EGEEFGRGEGIFDF------LRHMFRREGSKSE 538
            :||.|...|....|      ...:...|..|||
  Fly   512 DGERFAMNESCLYFPCLHKRRESLTEHEDRKSE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	228/504 (45%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	166/379 (44%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	230/506 (45%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	166/379 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471382
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3BGEV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7627
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0006714
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	10	9.810