DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and CG6126

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	137/586 - (23%)
Similarity:	250/586 - (42%)	Gaps:	110/586 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFA-------- 60
            |:::.|.|...:|||:...|.....:...||..|...::.||:|.|:.|.::|.|.:
  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSA 72

  Fly    61 -----------EIEKIYSQFEKPSCTRLEKIDEDGQNHTLSRERCNRWIYKYDFGYKSMNT-ELN 113
                       |:|         ||...:. ...|.|.|::   |.|::|...: ||:..| :.|
  Fly    73 ILAAIPLKPNGELE---------SCLMFDP-SSPGTNTTIN---CERYVYDTTY-YKTSRTIDWN 123

  Fly   114 WVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGR--------IRALILANWCGFLGDFSTIFA 170
            :|||..:...:.|::|.:|...|.:..|.|.|::||        :..||:.....|:.::
  Fly   124 FVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEY----- 183

  Fly   171 GSLTSFSISRFISGLAADANSYLM-YILILEYVSPSLRNV-GLN---TVLGSFYCLGLIGAC--- 227
               .||.::|::.|:...|.:|:. ::|.:|.|.|:.|.| |:.   ...|....:...||.
  Fly   184 ---FSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPD 245

  Fly   228 --WLAV--------WVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAK 282
              ||.|        ::|||                  :.:.||.:||..:.....|:..:.:..:
  Fly   246 RQWLQVIYGLHGCLFLGHW------------------WWLDESPRWLWMQGRAAEAVDIVAKGLR 292

  Fly   283 INRRQV-ADKDFKDFRIYCEQHYRKDKNQ-----EEHAKLLDMLKTPRMRSTAFKLLLIFIIIVP 341
            ||...: .||::         :.:|.|.|     :..|.|.|:.:||.:|.....:.|.:.....
  Fly   293 INGSGIPVDKEY---------YVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSL 348

  Fly   342 CYNTIARNVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVI 406
            .|..::.:...|..:|:::..:..|...||......:.||:||::.....|...|:..:.|. .|
  Fly   349 VYYGLSLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAA-YI 412

  Fly   407 SQGSNRNVLLLVG--LTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYI 469
            :|||..:..:::.  |.:|..|.|..      .:|.||.||.||...:.:..:....:..|:|.|
  Fly   413 AQGSTTSTAVVMAGKLLIAGSFAVIY------NYSAELFPTVVRNSAMGLGSMCARLSGALTPLI 471

  Fly   470 LHLGTYYKPAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREG 534
            ..|.::....|:::.|::.|...:..:.||||.|:.:|.|:.:||.||:|:..|.......:|:.
  Fly   472 TLLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIEDGENFGKGDTWFSQCAGRKKRQN 536

  Fly   535 S 535
            |
  Fly   537 S 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	125/549 (23%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	87/405 (21%)
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	125/550 (23%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	88/412 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	5.060