DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and CG8925

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_650526.1	Gene:	CG8925 / 41963	FlyBaseID:	FBgn0038404	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	120/543 - (22%)
Similarity:	216/543 - (39%)	Gaps:	92/543 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YQFVLLALYGYLMVVVSMHYFSQNVISFVP-DHWCYH-EQLENRSFAEIEKIYSQFEKPSCTRLE 78
            :|.:..||......:.:.|.|.. |....| |.||.. |.|...|.:|...| || ....|..|:
  Fly   160 WQSMWCALLSIFQAICTFHIFVY-VFQIAPKDFWCARPENLMQMSVSEWRNI-SQ-SSNGCLLLD 221

  Fly    79 KID------EDGQ------NHT-LSRERCNRWIYKY---DFGYKSMNTELNWVCDEAYKARVGQS 127
             :|      |:.|      |.| |...:|  |.:::   |...|::..|.:.||.....:.| ::
  Fly   222 -VDYTQVTYENNQLINWPENATDLGYRQC--WHFEFSDVDGSAKTLVQEFDLVCGRDILSLV-ET 282

  Fly   128 LFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTI---------FAGSLTSFSISRFIS 183
            .|.||:..|.:..|.:.||.||...|:.         |.||         |:.|:..|...|.|.
  Fly   283 CFLVGAAAGAVLSGWISDRFGRRHTLMA---------FVTIQSVFGGILAFSTSVAMFMSLRVII 338

  Fly   184 GLAADANSYLMYILILEYVSPSLRNV-GLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSSVPL 247
            |.|:...:.:.::|::|.||...|.| |:..:|.  ..:..:.:..||..:..||......|.|.
  Fly   339 GFASMTVTVVSFVLVVELVSGKWRTVIGILNILP--VAISYVLSAGLAYLIRDWRHLQLAISWPW 401

  Fly   248 LLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRK------ 306
            |::...:|.:.||.:||:.:..:|.....:||.|::|....:          ...:|||
  Fly   402 LIMLSIWFWLPESPRWLLAQGRLDELCGLIERAARMNGTSAS----------LPSNYRKTLEAAV 456

  Fly   307 ------------------------DKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIA 347
                                    |.:...|...|.::.:.:...|....|:|::.::..|..:.
  Fly   457 PRAVQSPPEATTSVESKAVEADAPDPSASGHVNPLLVVFSAKYWRTTCLTLVIWLTLIIIYFGLT 521

  Fly   348 RNVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNR 412
            .::..||.:.:|..::.......|..:..|:..::|.:.:.:|:|.:.|:..:|..||.:|..
  Fly   522 LHLSNLGGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGLCCLATNLVSNQTG-- 584

  Fly   413 NVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYK 477
                ::.|...|:..:...:.....::....||.||..||.:.::|...|..|.|::..|.....
  Fly   585 ----VIALATIAKCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIALILVPFLWKLEHIDP 645

  Fly   478 PAPSIILGLLFLSGAYVCLLLPE 500
            ..|..::|:..|.||....|:.:
  Fly   646 LLPLNVMGVCGLIGAVAISLMKD 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	120/543 (22%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	87/411 (21%)
CG8925	NP_650526.1	MFS	277..667	CDD:119392	88/417 (21%)
CG8925	NP_650526.1	MFS_1	277..635	CDD:284993	80/385 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	5.060