DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and CG6006

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	118/525 - (22%)
Similarity:	214/525 - (40%)	Gaps:	67/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYH-EQLENRSFAEIEKIYSQFEKPSC 74
            |:..::|.::..|.....|..:.|..|....:...|.||.. .||::...|....:....:  :|
  Fly    90 GHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVATWRNLSGSVD--NC 152

  Fly    75 TRLEKID--EDGQNHTLSRE------------RCNRWIYK-YDFGYKSMNTELNWVCDEAYKARV 124
            .|.|.||  :.....||..:            .|.:|.|: .|....:..::.:.||::.:...|
  Fly   153 RRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVACEKWEYETNDNVGNTWTSQWDLVCEKEHLKNV 217

  Fly   125 GQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIF------AGSLTSFSISRFIS 183
            .:..|.:|...|.:..|.|.|:.||...|.::      ....|||      ..|...:...|.:.
  Fly   218 AEMFFLLGVATGGIISGYLSDKFGRKTMLFIS------AVLQTIFGLWLYICSSFELYLTLRALL 276

  Fly   184 GLAADANSYLMYILILEYVSPSLRNVGLNTVLGSF--------YCLGLIGACWLAVWVGHWRIFL 240
            ||.:.:.:|...||.:|||....|     |:.|.:        |.: :.|..:|.  ..:.|:.|
  Fly   277 GLVSVSVTYSGLILAIEYVDGKWR-----TIAGMYNLFPLPISYMI-ISGLAYLT--QDYQRLQL 333

  Fly   241 ACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYR 305
             |..:|.:.:...:|:|.||.:||:.:..:|...|.:|..||.|.||:.    .|:::
  Fly   334 -CIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLP----ADYQL------- 386

  Fly   306 KDKNQEEHAK-LLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLP 369
            ....||...: :..:.::..:|..:.....|:..:...|..|..|:...|.:.::..:|..|...
  Fly   387 TPPTQESSTQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLVEI 451

  Fly   370 PSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTMAARFGVSIADGA 434
            |:..:...:..::|:|......:...|:....|  .|::|....:.|.:...|..:|.:|..:..
  Fly   452 PAIAVAMYIITKVGKKWLFCATLICAGVACCCA--AITEGHADLLWLKITFLMMGKFTISAGNTI 514

  Fly   435 SSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLL---FLSGAYVCL 496
            ...::.||.||.:|..||...:||...|..|:||:..|.   |....:::.||   .:.|.:|.|
  Fly   515 MPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLN---KIEGHLLMTLLTAWSIFGGFVVL 576

  Fly   497 LLPET 501
            .||||
  Fly   577 FLPET 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	118/525 (22%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	88/389 (23%)
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	116/523 (22%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	88/387 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	5.060