DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14855 and slc22a2

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	594	Identity:	151/594 - (25%)
Similarity:	255/594 - (42%)	Gaps:	78/594 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHE-----------QLEN 56
            |||||.:.|...|.|..:...:..:.:..|..|.......|.|:|||...           .|::
Zfish     4 FEEILEEAGTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHWCRDPGVSEIRERCGWSLQD 68

  Fly    57 RSFAEIEKI-------YSQFEKPSCTRL-----------EKIDEDGQNHTLS---RERC-NRWIY 99
            ...|.:..|       |||     |.|.           |..|.|.....||   ...| :.|.|
Zfish    69 ARRATVPLINGSSGASYSQ-----CGRFDVDWNATGLSCENPDGDFNQSQLSVMPMMSCVDGWEY 128

  Fly   100 KYDFGYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGD 164
            .| .|.:|..||.:.||.:|:...:.|:...:|.:.|::|.|.|.|:.||:::.::.|:  |:|.
Zfish   129 DY-VGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMTNF--FIGV 190

  Fly   165 FSTIFAGS--LTSFSISRFISGLAADANSYLMYILILEYVS-PSLRNVGLNTVLGSFYCLGLIGA 226
            ...:.|.|  ..|..:.|.:.|........:.|:||.|.|. ...|.||:...|  |:.:|::..
Zfish   191 TGILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQL--FFSMGILLL 253

  Fly   227 CWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADK 291
            ..||.::.:||......:||.:....:|:.:.||.:||:|:|.:..|:...:.:||.||:.::.|
Zfish   254 PLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKENRKTLSKK 318

  Fly   292 --DFKDFRIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLG 354
              ..||..|          :....|..:|:.||.::|:..|.|...:......|..:...:..||
Zfish   319 IETLKDDNI----------DSGSTASFMDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGILG 373

  Fly   355 ISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVG 419
            .:.::.|.::.:...|:.:|..|..:|:||:..    .|...|.|.||.|:.:...:....|...
Zfish   374 GNVYVDFLISGIVELPAAFLILLTIERIGRRLP----FATANIVAGAACLITAFIPDSMFWLKSA 434

  Fly   420 LTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILH-LGTYYKPAPSII 483
            :....|.|:::|.......:|||.||.:|..||:|..........::|::|: |...:...|.||
Zfish   435 VACVGRLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELPLII 499

  Fly   484 LG-LLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSKSEVEMGPTIVE 547
            .| |.|::|..| ||||||:...||.::             |.:.|..|.:.:..:.:....::.
Zfish   500 FGALAFVAGGLV-LLLPETKGVPLPETI-------------DDIEHPNRNKENPQQSQQLENLMT 550

  Fly   548 EDTLINKPV 556
            .|...||.|
Zfish   551 SDVTKNKDV 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	137/535 (26%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	98/378 (26%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	139/537 (26%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	100/387 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950