DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and slc22a4

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	550	Identity:	143/550 - (26%)
Similarity:	238/550 - (43%)	Gaps:	68/550 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFV---PDHWC-YHEQLENRSFAEI 62
            |:::|.:..|....:|   |.::..|.:.:..:.|....|.||   |.|.| ..||:...|....
Zfish     3 DYDDITSFLGTWGPFQ---LTVFLALAISILPNGFVGLYIVFVGDTPAHECLIPEQINISSVWRD 64

  Fly    63 EKIYSQFE-----KPSCTRLEKIDEDGQ----NHT---------LSRERC-NRWIYKYDFGYKSM 108
            ..|.:|.:     :.||:|. ::|...|    |:|         :..|.| :.|.|..:|...::
Zfish    65 AAIPTQMQDGVLKRSSCSRY-RLDTLRQLSMLNYTPNVEVNLSQIETEPCVDGWSYSQEFYQSTI 128

  Fly   109 NTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSL 173
            .||.:.||:..||..:..|::|.|.:.||...|.:.||.||...|........:.....:|:.|.
Zfish   129 VTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTITILIQMFSPSW 193

  Fly   174 TSFSISRFISGLAADANSYLMYILILEYVSPSLRNV--GLNTVLGS-----FYCLGLIGACWLAV 231
            ..||...|..|.:..:|..:.|:|..|.:||:.|.:  .|...:||     |:.|.       |.
Zfish   194 EVFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFGSLGVFMGSGIGQMFFPLA-------AY 251

  Fly   232 WVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDF 296
            ::..||..:..:::..||....::.:.||.:||:::.....|...|.|.|:.||....:..|...
Zfish   252 FIRSWRWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAPEVIFSSS 316

  Fly   297 RIYCEQHYRKDKNQEEHAK-------LLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLG 354
            .|            ||.||       :||:|......||.....|::::|...|..:..|...|.
Zfish   317 EI------------EEAAKKRIQKHSILDILSNCNAVSTILICSLLWMVITMSYYALILNTTNLH 369

  Fly   355 ISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITG--IFAVAAGLVISQGSNRNVLLL 417
            .:|::.|.|:|:...|:..:..||.....|:......:.:.|  ||.:.......||....:.:|
Zfish   370 GNPYLNFFLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPTELQGLATALEML 434

  Fly   418 VGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSI 482
            ..|.:.|.|.|..|      .::||.||.||...:....:.....|.:||:|::||.||:..|.|
Zfish   435 GKLCVTAAFCVVYA------VTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYYRYIPYI 493

  Fly   483 ILGLLFLSGAYVCLLLPETRNKKLPMSLAE 512
            ::|.|.|....:.|||||::.|.||.::|:
Zfish   494 VIGGLALFSGVMSLLLPESKGKVLPETIAQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	138/534 (26%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	100/387 (26%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	140/536 (26%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	100/390 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950