DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and CG42269

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	189/546 - (34%)
Similarity:	296/546 - (54%)	Gaps:	36/546 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQ---FVLLALYGYLMVVVSMHYFSQNVISFVPD-HWCYHEQL-----EN 56
            |||::||...|...|||   |:.:..:.:.:..|   ||||..::.:|: |||:..:|     |.
  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFV---YFSQIFLTLIPEQHWCHVPELDGLDVEA 131

  Fly    57 RSFAEIEKIYSQFEKPSCTRLEKIDEDGQNHTLS-----RERCNR-WIYKY-DFGYKSMNTELNW 114
            |....|.....::.......:...|...|...::     :.:|.. |.|.: :..|.::.||.||
  Fly   132 RLALSIPMTNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATEQNW 196

  Fly   115 VCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSIS 179
            |||:|......||:||:|::.|.|.||.:.||.|||.|||..|..|.|....|.|..:...|:|.
  Fly   197 VCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIM 261

  Fly   180 RFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGAC---WLAVWVGHWRIFLA 241
            ||..|.|.|....:||||:||||.|..|....|..:..|: .|  .||   |:|.::..|::...
  Fly   262 RFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFF-TG--AACLLPWIAYFLADWKLLAI 323

  Fly   242 CSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRK 306
            .:|.||||.....|:|.|||:|||::..||.|:..|:::.|.|.|||..:.::.|...|:   |.
  Fly   324 VTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCK---RM 385

  Fly   307 DKNQEEHAK--LLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLP 369
            .:.:.::.|  :||:.|:||:|.|...|::|::.|...::...|||..||:..|..|:|...|..
  Fly   386 QEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTEL 450

  Fly   370 PSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTMAARFGVSIADGA 434
            |:..|..::.||.||:..|...|.::|:|::.| .|:..|.....|.::|     ||.|:|:...
  Fly   451 PADTLLTVILDRFGRRWLACSSMVLSGVFSLLA-TVVPVGIYSAALAIMG-----RFFVNISYNI 509

  Fly   435 SSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYVCLLLP 499
            ..|::.|::||.||.:.||.:|:.|:.||.::|::::|....:..|.||||:|.:.|..:.||||
  Fly   510 GLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLP 574

  Fly   500 ETRNKKLPMSLAEGEEFGRGEGIFDF 525
            ||.|..||.:|::|||||||:.|:||
  Fly   575 ETLNHVLPQTLSDGEEFGRGQSIWDF 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	171/516 (33%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	133/376 (35%)
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	157/486 (32%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	124/350 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471420
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	8.010