DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and CG10486

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	157/546 - (28%)
Similarity:	276/546 - (50%)	Gaps:	28/546 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFV-PDHWCY-----HEQLENRSF 59
            :||:::|...|...|:|..|.........:.:..|..|..:... |.::||     |..:|.|..
  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKE 158

  Fly    60 AEIEK----IYS--QFEKPSCTRLEKIDEDGQ--NHTLSRERCNR-WIYKYD-FGYKSMNTELNW 114
            ..|.|    .||  :....:.|::...:....  |.:|....|.: ::::.: ..::|...|..|
  Fly   159 LSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESATMEFGW 223

  Fly   115 VCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSIS 179
            :||:...|...|.:||:||:.|.||:|...|..||:.||:.:.:...:|..:|..:....:|:||
  Fly   224 LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAIS 288

  Fly   180 RFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSS 244
            ||:.|.:.|....::|||:||||.|..|.:..|..|..||....:...|:|:..|:||.|.:.:|
  Fly   289 RFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRFSSFTS 353

  Fly   245 VPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRKDKN 309
            :|::|....:.|:.|||:|||:..::|.|:..|:.|.::|::||:.:....|...|.|.|:::.:
  Fly   354 LPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCTQFYKEELD 418

  Fly   310 QEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGL-GISPFIMFSLNALTLPPSGY 373
            ..:.. :|.:.|..||......::||::.|...|:...|....| ..:.|:.|::...|..|...
  Fly   419 GRDFT-VLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTIACATELPGNI 482

  Fly   374 LQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTMAARFGVSIADGASSQF 438
            |..|..||.||:..:..:.:::|:|:: .|......:|..:..|.|     ||..:|......|:
  Fly   483 LVILTLDRAGRRWCSFFYTSLSGVFSL-LGASFQNRANMRMSALAG-----RFFSNICYNIGLQW 541

  Fly   439 STELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYVCLLLPETRN 503
            :.|::||.||.:|||.:|..||.|..:||.:::|......:..|:||.|.:.|..:.|.||||.|
  Fly   542 AAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPETLN 606

  Fly   504 KKLPMSLAEGEEFGRGEGIFDFLRHM 529
            .:||.:|::|.:||:.:.|:    ||
  Fly   607 HELPETLSDGAQFGKNQRIW----HM 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	145/512 (28%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	113/372 (30%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	147/514 (29%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	115/377 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471411
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	8.010