DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14855 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_941052.1	Gene:	Slc22a20 / 381203	MGIID:	2685809	Length:	556	Species:	Mus musculus

Alignment Length:	540	Identity:	125/540 - (23%)
Similarity:	230/540 - (42%)	Gaps:	43/540 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIEKI 65
            |.|.::|...|...|:|.|..||......:::.|.|.||..:..|.|.|.|..........:..:
Mouse     1 MAFTDLLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEPTTNVSGV 65

  Fly    66 Y-------SQFEKPS-CTRLEK-----IDEDGQNHTLSRERC-NRWIYKYDFGYKSMNTELNWVC 116
            :       :|...|. |.|..:     :..:..:|.::.|.| :.|:|.......::..|.:.||
Mouse    66 WLRAAIPLNQHGDPEPCRRYVEPQWALLKPNASSHGVATEGCKDGWVYDRSIFPSTIVMEWDLVC 130

  Fly   117 DEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSISRF 181
            :......:.||::..|.:.|...||.|.||:||...|:.:.....:...:|.:.||.:::.:.||
Mouse   131 EARTLRDLAQSIYMSGVLVGAALFGGLADRLGRKAPLVWSYLQLAVSGAATAYVGSFSAYCVFRF 195

  Fly   182 ISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSSVP 246
            :.|:...........|::|::....|.|. ..:||..:.||.:....:|..:..||......|.|
Mouse   196 LMGMTFSGIILNSLSLVVEWMPTRGRTVA-GILLGFSFTLGQLILAGVAYLIRPWRWLQFAVSAP 259

  Fly   247 LLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCE--QHYRKDK- 308
            .|:..|:.:.:.||::||:.......|::.|::||.:|.|:...:     |:..|  ..|.:|:
Mouse   260 FLVFFLYSWWLPESSRWLLLHGKAQQAVQNLQKVAMMNGRKAEGE-----RLTTEVVSSYIQDEF 319

  Fly   309 -NQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSG 372
             :......:||:.:||.:|.....|:.::......|..:|.:::..|:|.:::.:|..:...|:.
Mouse   320 ASVRTSNSILDLFRTPAIRRVTCCLMGVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGIIDIPAM 384

  Fly   373 YLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTMAARFGVSIADG--AS 435
            .:.......:||:||...::.:.|:..:|           |:.:...|........::..|  ||
Mouse   385 LVATTTMIYVGRRATVSSFLILAGLMVIA-----------NMFMPEDLQTLRTVQAALGKGCLAS 438

  Fly   436 S-----QFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLL-FLSGAYV 494
            |     .|:.||.||.:|..|:....|.......::|.|..||......|.:..|.. .|:|..|
Mouse   439 SFICVYLFTGELYPTEIRQMGMGFASVNARLGGLVAPLITTLGEISPVLPPVSFGATSVLAGMAV 503

  Fly   495 CLLLPETRNKKLPMSLAEGE 514
            ...|.||||..|..::|..|
Mouse   504 ACFLTETRNVPLVETIAAME 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	119/521 (23%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	87/383 (23%)
Slc22a20	NP_941052.1	2A0119	11..518	CDD:273328	120/523 (23%)
		MFS	138..507	CDD:119392	88/385 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..556
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843543
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950