DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and CG4630

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	151/587 - (25%)
Similarity:	254/587 - (43%)	Gaps:	86/587 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFV-----PDHWCYHEQLENRSFA 60
            :||::||.:.|...|:|     ...||::.:.:.:.:.|.:|:|     |.:.||..:.:....|
  Fly    13 LDFDDILVEIGEFGRFQ-----RRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDA 72

  Fly    61 E---------IEKIYSQ---FEKPSCTR-------LEKIDED----------GQNHTLSRERCNR 96
            |         :...:|:   |...:|.|       ||...:.          .:|.|...||||:
  Fly    73 EYGANWVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQ 137

  Fly    97 WIYKYDFGYKSMNTELNW--VCDE-AYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANW 158
            ::|    |.........|  .|.| .:|.....::.|.|.|.||...|.|.||.||....:....
  Fly   138 FVY----GSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIV 198

  Fly   159 CGFLGDFSTIFAGSLTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLG- 222
            ...|...:...:....||.....::.:.......|.:|:.:|.|.|..|.:. :.||..||.:|
  Fly   199 FMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMS-SIVLNYFYAVGE 262

  Fly   223 -LIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRR 286
             |:|   |:|::..||......|||.|:...:::||.||.:||:.||..:.|...:.|.||:|||
  Fly   263 ALLG---LSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR 324

  Fly   287 QVADKDFKDFRIYCEQHYRKDKNQEE------HAK--------LLDMLKTPRMRSTAFKLLLIFI 337
            .::.:....|:   :|....:..||:      |.|        :.::.::..:......||||:.
  Fly   325 DISVELMASFK---QQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWA 386

  Fly   338 IIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAA 402
            :....|..::.|...|..:.::.|:|..|...|...|..|...|.||:....|.:.:..|..||:
  Fly   387 VNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVAS 451

  Fly   403 GLV-ISQG---------------SNRNVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRG 451
            |.| ::||               |..| .|:|.|.:..:.|::.:......|:.|::||.:|..|
  Fly   452 GFVTLAQGDWIPCQTGVESRHSWSCAN-WLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGG 515

  Fly   452 VAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEF 516
            |.|:.......:.|:|::..|.:||.|.|.::.|.|.|....:.||||||.|:|||.::.|....
  Fly   516 VGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIAL 580

  Fly   517 GR 518
            |:
  Fly   581 GK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	143/564 (25%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	106/403 (26%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	145/566 (26%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	97/382 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458511
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.990