DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a30

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_795976.1	Gene:	Slc22a30 / 319800	MGIID:	2442750	Length:	552	Species:	Mus musculus

Alignment Length:	601	Identity:	155/601 - (25%)
Similarity:	256/601 - (42%)	Gaps:	103/601 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEI-EK 64
            |.|:|:|.:.|:..|:|.:.::...:|:.:|..|...:|..:.:|:|.|:...|:|.:.::. .:
Mouse     1 MAFQELLNQVGSLGRFQILQISFVLFLVGLVVPHITMENFTAAIPNHRCWAPILDNDTASDNGSR 65

  Fly    65 IYSQ-------FEKPSCTRLEKIDEDGQ--------NHTLSRER------C-NRWIYKYDFGYKS 107
            |.||       ....|..||:|.....|        |.|.|.|.      | :.|:|.......:
Mouse    66 ILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTFSNETEPDTEPCVDGWVYDRSNFLST 130

  Fly   108 MNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGS 172
            :.||.:.||:......|.:..|.:|...|.:..|.|.||.||...|..|.....:.:....||.|
Mouse   131 IVTEWDLVCESQALNSVAKFSFMIGLFIGAIICGHLSDRFGRKFILTCALLQFAITETCVAFAPS 195

  Fly   173 LTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIG---ACWLAVWVG 234
            ...:.:.||::|::.:..|...::|:||:.||..  :|:..||.|  |...||   ...||....
Mouse   196 FFIYCLLRFLAGMSVEPISVNSHLLMLEWTSPKF--LGMVAVLTS--CAASIGYMILAGLAFLFR 256

  Fly   235 HWRIFLACSSVPLLLVTLFYFLV-----QESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFK 294
            .||......|||     :|:||:     .|||:||:..|.....::.|.:||.:|..:.:..
Mouse   257 IWRHLQLAMSVP-----IFFFLILTRWMSESARWLIVTNKPQKGLKELRKVAHMNGMKNSGN--- 313

  Fly   295 DFRIYCEQHYRKDKNQEEHAKL----LDMLKTPRMRS----TAFKLLLIFIIIVPCYNTIARNVE 351
              .:..|......||:.|.||.    .|:..||.:|.    .:|...|..|.|
Mouse   314 --TLTMEVVEASMKNELEAAKRKSSPRDLFHTPILRKRICVLSFMRYLFTISI------------ 364

  Fly   352 GLGISPFIM-FSLNALTLPPSGYLQGLL--------QDRMGRKATAVGWMAITGIFAVAAGLVIS 407
             .|:|..:. .|.|.:.|.......|:|        .:.|||:.|.:..|::.|||.:.|..|..
Mouse   365 -FGLSLHLQHLSTNIILLQFLSSALGILISVIGHFVLNHMGRRITQLVLMSLRGIFMLTAVFVPQ 428

  Fly   408 QGSNRNVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHL 472
            :   ...|.::..|:||... |:....|:....||:||::|..|:.|:.:.|.:..||:|..:.|
Mouse   429 E---MQTLRIIMATLAAALS-SLCMCVSNLHINELLPTTLRATGMGVIAMFGNSGLFLAPLFMLL 489

  Fly   473 GTYYKPAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAE-GEEFGRGEGIFDFLRHMFRREGSK 536
            .||....|.|..|...:...:...|||||:|:.||.|:.: |.::               :|..:
Mouse   490 ATYSANLPWIFYGGFSILYGFSVFLLPETKNQPLPDSIHDVGNDW---------------KESRQ 539

  Fly   537 SEVEMGPTIVEEDTLI 552
            ::        |||::|
Mouse   540 AK--------EEDSII 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	142/543 (26%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	105/396 (27%)
Slc22a30	NP_795976.1	2A0119	11..525	CDD:273328	143/544 (26%)
Slc22a30	NP_795976.1	MFS	151..516	CDD:119392	105/395 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940