DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	142/581 - (24%)
Similarity:	239/581 - (41%)	Gaps:	72/581 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFA------ 60
            |::|:.|..|....:|.::..|....::....:..|...::..|:|.|......|.|.|
  Rat     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSI 67

  Fly    61 EIEKIYSQFEKPSCTRLEKID---------EDGQN---HTLSRERC-NRWIYKYDFGYKSMNTEL 112
            .:|....:....||.|.....         |.|::   ..|.:|.| :.|.|..|....::.||.
  Rat    68 PLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDVFLSTIVTEW 132

  Fly   113 NWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALIL--ANWCGFLGDFSTIFAGSLTS 175
            :.||.:.:||.:..||||||.:.|:...|.|.||.||...|.|  ....||  .|..:|:.:...
  Rat   133 DLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGF--SFLQLFSVNFEM 195

  Fly   176 FSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFL 240
            |::...:.|:...:|....::|..|.:|.|:|.:.....:..||..|.:.....|.::..||:.|
  Rat   196 FTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLL 260

  Fly   241 ACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYR 305
            ...:||.:|....::.:.||.:||:::..|..|...:.:.||.|........|....:   |...
  Rat   261 LALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFDPSEL---QDLN 322

  Fly   306 KDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPP 370
            ..|.|..|  :.|:::|..:|......:::::.|...|..::.:...|....::...|.|....|
  Rat   323 SKKPQSHH--IYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVP 385

  Fly   371 SGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLV------------GLTMA 423
            :..|..||...:.|:            ::::|.|.:. ||   |||.:            .|.|.
  Rat   386 AYVLAWLLLQHLPRR------------YSISAALFLG-GS---VLLFIQLVPSELFYLSTALVMV 434

  Fly   424 ARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLF 488
            .:||::.|......::.||.||.||..||.|...|....|.||||.::||.|.:..|.|::|.|.
  Rat   435 GKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLT 499

  Fly   489 LSGAYVCLLLPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSKSEVEMGPTIVEED 549
            :..|.:.|..||:....||                |.:..|.|.:|.|.......|..::|
  Rat   500 ILTAILTLFFPESFGAPLP----------------DTIDQMLRVKGIKQWQIQSQTRTQKD 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	130/528 (25%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	100/385 (26%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	132/546 (24%)
		MFS	123..510	CDD:119392	106/409 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557		2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347287
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950