DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	129/568 - (22%)
Similarity:	253/568 - (44%)	Gaps:	34/568 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRS------- 58
            |.|.::|.:.|...|:|.:.:.:....:::::.|...||..:.:|.|.|......|.|
  Rat     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEA 65

  Fly    59 FAEIEKIYSQFEKPSCTRLEK-------IDEDGQNHTLSRERC-NRWIYKYDFGYKSMNTELNWV 115
            :..::|   |.:..||.|...       .:....|.|...|.| :.|:|.......::.||.|.|
  Rat    66 WLPLDK---QGQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLV 127

  Fly   116 CDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSISR 180
            |......::.|||:.||.:.|.:.||.|.||:||.:.|||......:......:|.:.|.:.:.|
  Rat   128 CSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFR 192

  Fly   181 FISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSSV 245
            .:||::..:.:.....|.:|:: |......:.|::|..|.||......:|..|.|||......||
  Rat   193 LLSGMSLASIAINCMTLNVEWM-PIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSV 256

  Fly   246 PLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQV--ADKDFKDFRIYCEQHYRKDK 308
            |..:..::.:...|||:|..:...:|..:|.|:|||:||.:|.  |....:..|...::.....|
  Rat   257 PFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKELTLSK 321

  Fly   309 NQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSGY 373
            .|   |..:::|:.|.:|.....|.:::......|..:..:::|.|:|.:::..:......|:.:
  Rat   322 GQ---ASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKF 383

  Fly   374 LQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTMAARFGVSIADGASSQF 438
            :..|:.:.|||:...:..:.:.||..:..|::    ...:.::...|.:..:..::.:......:
  Rat   384 VCFLVINSMGRRPAQMASLLLAGICILVNGII----PKSHTIIRTSLAVLGKGCLASSFNCIFLY 444

  Fly   439 STELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYVCLLLPETRN 503
            :.||.||.:|..|:.:........|.:||.:.....:|...|..|.|.:.:..:.|..|||||..
  Rat   445 TGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLG 509

  Fly   504 KKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSKSEVEMGPTIVEEDTL 551
            :.||.::.:.:...||:      ::..::|..|..:.:..:..|::.|
  Rat   510 QPLPDTVQDLKSRSRGK------QNQQQQEQQKQMMPLQASTQEKNGL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	118/512 (23%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	86/373 (23%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	120/514 (23%)
		MFS	135..505	CDD:119392	87/377 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		5/42 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347403
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950