DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_113772.1	Gene:	Slc22a2 / 29503	RGDID:	61936	Length:	593	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	137/571 - (23%)
Similarity:	246/571 - (43%)	Gaps:	97/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEILAKCGNSSRYQ---FVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYH---EQLENR-SFAE 61
            ::||...|....:|   |.||||.......:   |.....:.|.|||.|:.   .:|..| .:::
  Rat     5 DDILEHIGEFHLFQKQTFFLLALLSGAFTPI---YVGIVFLGFTPDHHCWSPGAAKLSQRCGWSQ 66

  Fly    62 IEKIYSQFEKP------------SCTRLE------KIDEDGQNHTLSRER-------CNR-WIYK 100
            .|::  .:..|            .|.|.|      .:|......:|:.:|       |.. |:
  Rat    67 AEEL--NYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQLPLGPCEHGWV-- 127

  Fly   101 YDFGYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDF 165
            |:....|:.||.|.||..::...:.||:..||...|.:..|.|.||.||       .:|..:...
  Rat   128 YNTPGSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGR-------KFCLLVTIL 185

  Fly   166 STIFAGSLTSFS-------ISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFY---- 219
            ....:|:|.:.|       :.||:.||.:.|...:.||||.|:|     .:|...::|..|
  Rat   186 INAISGALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFV-----GLGYRRMVGICYQIAF 245

  Fly   220 CLGLIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKIN 284
            .:||:....:|..:.:||......::|.....|:::.:.||.:||:::|.:..|::.::.:||.|
  Rat   246 TVGLLILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKN 310

  Fly   285 RRQVADKDFKDFRIYCEQHYRKDKNQEEHAK--LLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIA 347
            .:.|.         ...|:...|::..:..|  :||:::||::|.....|:         ||...
  Rat   311 GKSVP---------VSLQNLTPDEDAGKKLKPSILDLVRTPQIRKHTLILM---------YNWFT 357

  Fly   348 RNV--EGL-------GISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAG 403
            .:|  :||       |.:.::.|..:||...|:.::..|..||:||:   ..| |::.:.|.||.
  Rat   358 SSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRR---YPW-AVSNMVAGAAC 418

  Fly   404 LVISQGSNRNVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPY 468
            |......:....|.:.:....|.|:::|.......:.||.||.:|..||.|..........::|:
  Rat   419 LASVFIPDDLQWLKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITPF 483

  Fly   469 ILH-LGTYYKPAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGR 518
            ::: |...:...|.::..::.|....:.||||||:.|.||.::.:.|...|
  Rat   484 LVYRLTDIWMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDAENMQR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	131/551 (24%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	93/394 (24%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	133/553 (24%)
Slc22a2	NP_113772.1	MFS	125..492	CDD:119392	98/402 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950