DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001381833.1	Gene:	Slc22a20 / 293686	RGDID:	1311460	Length:	556	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	128/539 - (23%)
Similarity:	230/539 - (42%)	Gaps:	41/539 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYH-----EQLENRSFA 60
            |.|.::|...|...|:|.|..||......:::.|.|.||..:..|.|.|.|     |...|.|.|
  Rat     1 MAFTDLLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEATTNDSGA 65

  Fly    61 EIEKI--YSQFEKPS-CTRLEK-----IDEDGQNHTLSRERC-NRWIYKYDFGYKSMNTELNWVC 116
            .:...  .:|...|. |.|..:     ::.:..:|.::.|.| :.|:|.......::..|.:.||
  Rat    66 WLRATIPLNQHGVPEPCQRYTEPQWALLEPNTSSHGVATEGCKDGWVYDRSIFPSTIVMEWDLVC 130

  Fly   117 DEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSISRF 181
            :......:.||::..|.:.|...||.|.||:||...|:.:.....:....|.:.||.:::.|.||
  Rat   131 EARTLRDLAQSIYMSGVLVGAALFGSLADRLGRKAPLVWSYLQLAVSGAVTAYVGSFSAYCIFRF 195

  Fly   182 ISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSSVP 246
            :.|:...........|::|::....|.|. ..:||..:.||.:....:|..:..||......|.|
  Rat   196 LMGMTFSGIILNSLSLVVEWMPTRGRTVA-GILLGFSFTLGQLILAGVAYLIRPWRWLQFAVSAP 259

  Fly   247 LLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRI---YCEQHYRKDK 308
            .|:..|:.:.:.||::||:.......|::.|.:||.:|.|: |:.:.....:   |.:..:...:
  Rat   260 FLVFFLYSWWLPESSRWLLLHGKAQQAVQNLRKVAMMNGRK-AEGERLTIEVVSSYIQNEFASVR 323

  Fly   309 NQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSGY 373
            ...   .:||:.:||.:|.....|::::......|..:|.:::..|:|.:::.:|..:...|:..
  Rat   324 TSN---SILDLFRTPGIRKVTCCLMMVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGIIDIPAML 385

  Fly   374 LQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTMAARFGVSIADG--ASS 436
            :.......:||:||...::.:.|:..:|           |:.:...|........::..|  |||
  Rat   386 VATTTMIYVGRRATVSSFLVLAGLMVIA-----------NMFVPEDLQTLRTVQAALGKGCLASS 439

  Fly   437 -----QFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLL-FLSGAYVC 495
                 .|:.||.||.:|..|:....|........:|.|..||......|.:..|.. .|:|..|.
  Rat   440 FICVYLFTGELYPTEIRQMGMGFASVNARLGGLAAPLITTLGEISPVLPPVSFGATSVLAGMAVI 504

  Fly   496 LLLPETRNKKLPMSLAEGE 514
            ..|.||||..|..::|..|
  Rat   505 CFLTETRNVPLVETIAAME 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	122/520 (23%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	86/382 (23%)
Slc22a20	NP_001381833.1	MFS_SLC22A6_OAT1_like	103..508	CDD:341004	94/420 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940