Protein Alignment CG14855 and SLC22A24

DIOPT Version :9

• Sequence 1: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_001129978.2
• Gene: SLC22A24 / 283238
• HGNCID: 28542
• Length: 552
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 142/569 - (24%)
• Similarity: 246/569 - (43%)
• Gaps: 93/569 - (16%)

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIEKI 65
            |.|:.:|.:.|...|:|..|:|.:....:::..:...:|..:|.|.|.|:...|:|.:.::.:.
Human     1 MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDNDT- 64

  Fly    66 YSQFEKPSCTRLE-KIDEDGQNHTLSRERCNR-----------------------------WIYK 100
             ....|....|:. .:|.:     |..::|.|                             |:|.
Human    65 -GTLSKDDLLRISIPLDSN-----LRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVYD 123

  Fly   101 YDFGYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGR-------IRALILANW 158
            ......::.||.:.||:......:.||||..||:.|.|.:|.|.||:||       ...|.::|.
Human   124 RSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNT 188

  Fly   159 CGFLGDFSTIFAGSLTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLG- 222
            |       ..||.:...:.|.||::|.:........:||.||:..|..|::.:..:|.| |.:|
Human   189 C-------AAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS-YSVGQ 245

  Fly   223 -LIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRR 286
             |:|.  ||..:..|.|.....|.|::::.|..:.:.|||:||:..|.:|..::.|.|||.||.:
Human   246 MLLGG--LAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGK 308

  Fly   287 QVADKDFKDFRIYCEQHYRKDKNQEEHA-----KLLDMLKTPRMRSTAFKLLLI-FIIIVPCYNT 345
            :..::..      ..:..|....:|..|     .:..:.:.|::|...|.|..: |.|.||.|..
Human   309 KNTEETL------TTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGL 367

  Fly   346 IARNVEGLG--ISPF------IMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAA 402
            |. |::.||  :|.|      :.|:...::|        |..:.|||:.:.:.:....|:| :..
Human   368 IL-NLQHLGSNVSLFQILCGAVTFTARCVSL--------LTLNHMGRRISQILFTFPVGLF-ILV 422

  Fly   403 GLVISQGSN--RNVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFL 465
            ...:.|...  |.||..:|:.     .||.|..::|....||:||.:|.....:..|:|...:.|
Human   423 NTFLPQEMQILRVVLATLGIG-----SVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAAL 482

  Fly   466 SPYILHLGTYYKPAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGE 514
            :|.::.|..|....|.|..|:..:....|.|||||||:..||.::.:.|
Human   483 APLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVE 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	136/550 (25%)
		MFS	127..499	CDD:119392	106/396 (27%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	113/437 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153828
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950