DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14855 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	141/571 - (24%)
Similarity:	240/571 - (42%)	Gaps:	97/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEILAKCGNSSRYQ---FVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIEKI 65
            :::|.:.|....:|   |:||.|....:..:   |.....:.|.|.|:|     :|...||:.:.
  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPI---YVGIVFLGFTPGHYC-----QNPGVAELSQR 61

  Fly    66 --YSQFEK---------PS--------CTRLEKIDEDGQNHT------LSRERCNR--------- 96
              :||.|:         ||        |.|.|   .|....|      ||....||
  Rat    62 CGWSQAEELNYTVPGLGPSDEASFLSQCMRYE---VDWNQSTLDCVDPLSSLVANRSQLPLGPCE 123

  Fly    97 --WIYKYDFGYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWC 159
              |:  ||....|:.||.|.||.:|:|..:.||...:|...|:|..|.:.||.||...|::....
  Rat   124 HGWV--YDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLV 186

  Fly   160 GFLGDFSTIFAGSLTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSF-YCLGL 223
            ..:....|..|...||..:.|.:.|:.:..:....|.||.|:|....|..  ..:|... :.:||
  Rat   187 TSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRT--TAILYQMAFTVGL 249

  Fly   224 IGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQV 288
            :|...:|..:..||......|:|..|..|:|:.|.||.:||:::.....|:|.:|        |:
  Rat   250 VGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIME--------QI 306

  Fly   289 ADKDFK----DFRIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARN 349
            |.|:.|    |.::.|   ..:|.:::......|:.:||.:|.....|:.::......|..:..:
  Rat   307 AQKNGKVPPADLKMLC---LEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMH 368

  Fly   350 VEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNV 414
            |...|.:.::.|..::|...|:.::..:..||:||            |:.:||..:::..:   .
  Rat   369 VGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGR------------IYPIAASNLVTGAA---C 418

  Fly   415 LLLV---------GLTMA--ARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPY 468
            ||::         .:|:|  .|.|.:|........:.||.||.:|..|:.|...........:|:
  Rat   419 LLMIFIPHELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPF 483

  Fly   469 -ILHLGTYYKPAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGR 518
             :..|...::..|.|:.|:|.|:...:.||||||:...||.::.|.|..||
  Rat   484 MVFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	134/551 (24%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	90/388 (23%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	136/553 (25%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	102/419 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347304
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950