DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a29

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_766364.1	Gene:	Slc22a29 / 236293	MGIID:	3605624	Length:	551	Species:	Mus musculus

Alignment Length:	543	Identity:	140/543 - (25%)
Similarity:	238/543 - (43%)	Gaps:	52/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEI-EK 64
            |.|:|:|.:.|:..|:|.:.:.....|..:|..|...:|..:.:|:|.|:...|:|.:.::. .:
Mouse     1 MSFQELLNQVGSLGRFQILQIVFLFLLNAIVVPHIGMENFTAAIPNHRCWVPILDNDTASDNGSR 65

  Fly    65 IYSQ-------FEKPSCTRLEKIDEDGQ--------NHTLSR------ERC-NRWIYKYDFGYKS 107
            |.||       ....|..||:|.....|        |.|.|.      |.| :.|:|.......:
Mouse    66 ILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDRSNFLST 130

  Fly   108 MNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGS 172
            :.||.:.||:......|.:..|.:|...|.:..|.|.||.||...|..|.....:.:....||.|
Mouse   131 IVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPS 195

  Fly   173 LTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYC---LGLIGACWLAVWVG 234
            ...:...||::|::.:..|...::|:||:.||..  :.:..||.|  |   :|.:....||....
Mouse   196 FFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKF--LAMMAVLSS--CAPNIGFMILAGLAFLFR 256

  Fly   235 HWRIFLACSSVPLLLVTLFYFLV-----QESAQWLVTRNDVDGAIRRLERVAKIN-RRQVADKDF 293
            .|.......|.|     :|:||:     .|||:||:..|.....::.|.:||.:| .:...|...
Mouse   257 IWHHLQLTMSAP-----IFFFLILTRWLSESARWLILINKPQKGLKELRKVAHMNGMKNSGDLTM 316

  Fly   294 KDFRIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPF 358
            :..|...:......|.:   ..|.|:..|..:|.....|..|.:........:|.:::.|..:..
Mouse   317 EIVRTSMKAELEAAKTK---PSLRDLFHTSILRKRICVLSFIRLFFTVSIIGLAVHLQHLSSNII 378

  Fly   359 IM-FSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTM 422
            :: |.::||.:..| .:...:.:.:||:.|.:..|::.|||.:.|..|..:   ...|.::..|:
Mouse   379 LLQFLISALAILVS-VIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQE---MQTLRIIMATL 439

  Fly   423 AARFGV-SIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGL 486
            |.  |: |:..|.|...:.||:||::|...:.|:...|.:..||||..:.:.|||...|.|..|.
Mouse   440 AG--GISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIFYGG 502

  Fly   487 LFLSGAYVCLLLPETRNKKLPMS 509
            ..:..|:...|||||:|:.||.|
Mouse   503 FSIFNAFTVFLLPETKNQPLPDS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	133/529 (25%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	96/382 (25%)
Slc22a29	NP_766364.1	MFS_OAT	109..515	CDD:340932	105/423 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940