DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus

Alignment Length:	559	Identity:	143/559 - (25%)
Similarity:	238/559 - (42%)	Gaps:	73/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEILAKCGNSSRYQ---FVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYH---EQLENR---SF 59
            :::|...|....:|   |:||.|....:..:   |.....:.|.|||.|..   .:|..|   |.
Mouse     5 DDVLEHVGEFGWFQKQAFLLLCLISASLAPI---YVGIVFLGFTPDHHCRSPGVAELSQRCGWSP 66

  Fly    60 AE-----IEKIYSQFEKPSCTRLEKIDEDGQNHT------LSRERCNR-----------WIYKYD 102
            ||     :..:.|..|....::..|.:.|....|      ||....||           |:  ||
Mouse    67 AEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWV--YD 129

  Fly   103 FGYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFST 167
            ....|:.||.|.||.:|:|..:.||...:|...|:|..|.:.||.||...|::......|....|
Mouse   130 TPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLSGVLT 194

  Fly   168 IFAGSLTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSF-YCLGLIGACWLAV 231
            ..|...||..:.|.:.|:.:..:....|.||.|:|....|..  ..:|... :.:||:|...:|.
Mouse   195 AVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRT--TAILYQVAFTVGLVGLAGVAY 257

  Fly   232 WVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDF 296
            .:..||......|:|..|..|:|:.|.||.:||:::.....|:|.:|::|:.||: |...|.|
Mouse   258 AIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRK-VPPADLK-- 319

  Fly   297 RIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMF 361
             :.|   ..:|.::.......|:.:||.:|.....|:.::......|..:..:|...|.:.::.|
Mouse   320 -MMC---LEEDASERRSPSFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANLYLDF 380

  Fly   362 SLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLV-------- 418
            ..::|...|:.::..:..||:||            |:.:||..:::..:   .||::
Mouse   381 FYSSLVEFPAAFIILVTIDRIGR------------IYPIAASNLVAGAA---CLLMIFIPHELHW 430

  Fly   419 -GLTMA--ARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPY-ILHLGTYYKPA 479
             .:|:|  .|.|.:|........:.||.||.:|..|:.|...........:|: :..|...::..
Mouse   431 LNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQAL 495

  Fly   480 PSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGR 518
            |.|:.|:|.||...|.||||||:...||.::.|.|..||
Mouse   496 PLILFGVLGLSAGAVTLLLPETKGVALPETIEEAENLGR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	136/539 (25%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	94/384 (24%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	138/541 (26%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	106/415 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843896
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950