DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14855 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	537	Identity:	142/537 - (26%)
Similarity:	231/537 - (43%)	Gaps:	48/537 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIEKI 65
            |.|.|||.:.|:...:|::.:.|....::.::.|...|...:..|||.|  ....|.|.......
Mouse     1 MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHC--RPPPNASLEPWVLP 63

  Fly    66 YSQFEKP-SCTRL-----EKIDEDGQNHTLSRERC-NRWIYKYDFGYKSMNTELNWVCDEAYKAR 123
            .....|| .|.|.     ..:..|.|..|   |.| :.||  |:....::.||.:.||.......
Mouse    64 LGPNGKPEKCLRFVHLPNASLPNDTQGAT---EPCLDGWI--YNSTRDTIVTEWDLVCGSNKLKE 123

  Fly   124 VGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFL---GDFSTIFAGSLTSFSISRFISGL 185
            :.||:|..|.:.|...||.|.||.||...|   .|...|   ...|..|:.|||.:.|.||:.|.
Mouse   124 MAQSVFMAGILVGGPVFGELSDRFGRKPIL---TWSYLLLAASGSSAAFSPSLTVYMIFRFLCGC 185

  Fly   186 AADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSSVPLLLV 250
            :....|....||.:|:|..|.|.:. :|.:|..|.:|......||..|..||......|....:.
Mouse   186 SISGISLSTIILNVEWVPTSTRAIS-STTIGYCYTIGQFILPGLAYAVPQWRWLQLSVSAAFFIF 249

  Fly   251 TLFYFLVQESAQWLVTRNDVDGAIRRLERVAKIN-RRQVADKDFKDFRIYCEQ---HYRKDKNQE 311
            :|..:.|.||.:|||.......|::.|:|||..| :::..:|      :..|:   :.:||...
Mouse   250 SLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEK------LTVEELKFNLQKDITS- 307

  Fly   312 EHAK----LLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSG 372
              ||    |.|:.:...:|...|.|.|.:......|.::|..||..|::.:|:..:......|:.
Mouse   308 --AKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAK 370

  Fly   373 YLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTMAARFGVSIADGASS- 436
            ::..|....:||:.|. |::.|....|:.|.:.:|  |...:|    .|..|.||.....|:.|
Mouse   371 FITILSISYLGRRITQ-GFLLILAGVAILALIFVS--SEMQLL----RTALAVFGKGCLSGSFSC 428

  Fly   437 --QFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYVCLLLP 499
              .:::||.||.:|..|:.:.::.....|.::|.:...|......|::|.|.:.|.|......|.
Mouse   429 LFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLL 493

  Fly   500 ETRNKKLPMSLAEGEEF 516
            ||.|:.||.::.:.:::
Mouse   494 ETLNRPLPETIEDIQDW 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	135/516 (26%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	103/385 (27%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	137/518 (26%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950