DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14855 and Y57G11C.23

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_502801.2	Gene:	Y57G11C.23 / 190377	WormBaseID:	WBGene00013318	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	125/548 - (22%)
Similarity:	206/548 - (37%)	Gaps:	150/548 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVVVSMHYFSQNVISFV------------PDHWCYHEQLENRSFAEIEKIYSQFEKPSCTRLEK 79
            ||::..|..|....:.||            .|.:||  :|:|       |..|.|::.|
Worm    14 LMILYQMTLFFSVQMLFVIFLEYMPKTHCTEDRYCY--KLKN-------KCMSDFDRHS------ 63

  Fly    80 IDED-----GQNHTLSRERCNRW-IYKYDFGYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTL 138
             |.|     ..|........|:. .|...:.|:...|.|.:..        ..:..|:|::.|.|
Worm    64 -DSDVCPFASTNFDQCVVAANKTDFYSAQYEYQQDCTGLKYFS--------SSTSTFLGTLVGNL 119

  Fly   139 AFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLT---SFSISRFISGLAADANSYLMYILILE 200
            ..|.|.|.|||....|.:.   .||..|.|.:.:|.   ||.|.||:.|.|......:.:....|
Worm   120 ILGYLSDTIGRRPVYIFSI---LLGVPSVILSAALNDVMSFYIFRFLVGFAIAGTLTVGWTYASE 181

  Fly   201 YVSPSLR----------NVGLNTVLGSFYCLGLIGACWLAVWVGHWRI--FLACSSVPLLLVTLF 253
            .|.||.|          |..:..|          |..|||   |.||:  :| |:::...::.:.
Worm   182 MVIPSRRFRLRTFPNWANARMMQV----------GVSWLA---GEWRLASYL-CAALSATVLPMI 232

  Fly   254 YFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHYRKDKNQEEHAKL-- 316
            ::| .||..:|..:.....|.|..|::|.|                |:..| :.|.:||...|
Worm   233 WYL-PESPVFLEQKKKYKRAERSREKIAGI----------------CQLEY-EPKAREEMQDLKK 279

  Fly   317 ---LDMLKTPRMRSTAFKLL--LIFIIIVPCYNTIARN---VEGLGISPFIMFSLNALTLPPSGY 373
               :.:||:|.:| |.|.:|  :.|.:.:..|.|...:   .|...:..|    |..|.|..|..
Worm   280 ITPIKLLKSPVLR-TNFLVLCWMWFYVGMSVYITDLNSGDMAENFYVGQF----LCGLVLTVSKI 339

  Fly   374 LQGLLQDR---MGRKATAVGWMAITGIFAVAAGLVISQGS-NRN----------VLLLVGLTMAA 424
            :.|:|:.:   :||:...:.    :.|.|:.|.:.|.... .||          :|...|.::..
Worm   340 MIGILEPKIPWLGRRCLFIS----SQIIAILAYITILTALWTRNKVSWWYTVAYILAYAGQSLCL 400

  Fly   425 R-FGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLF 488
            . ..:|:|         ||:||.||....|::::.....:.|:.....:..:|:|       |||
Worm   401 ETCYLSLA---------ELMPTDVRTISGALMNILMKIGTILASTTKPIKFWYEP-------LLF 449

  Fly   489 LSGAYVCL--------LLPETRNKKLPM 508
            :....:|.        .|||::|..:.:
Worm   450 IINTIICTGGLIIVWKYLPESKNMNMQL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	125/545 (23%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	98/419 (23%)
Y57G11C.23	NP_502801.2	2A0119	<107..473	CDD:273328	101/425 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910