DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and F45E10.2

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001022174.1	Gene:	F45E10.2 / 185801	WormBaseID:	WBGene00009729	Length:	538	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	128/530 - (24%)
Similarity:	234/530 - (44%)	Gaps:	83/530 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIEKIYSQ 68
            |.|....|:..|:|.:...|....:..||||..|          |.:       ..:...||.::
Worm    69 ESIFEGLGSFGRFQQIQFILICIPIAFVSMHVMS----------WTF-------VVSPARKICNE 116

  Fly    69 FEKPSCTRLEKIDEDGQNHTLSRERCNRWIYKYDFGYKSMNTELNWVCDEAYKARVGQSLFFVGS 133
            ..:   ||::..:|      |:....:||         .|:.:..|:     :|.| |:::|:|.
Worm   117 TNE---TRIDGCEE------LAYSASDRW---------EMDGDNGWI-----RATV-QAVYFIGQ 157

  Fly   134 VCGTLAFGLLGDRIGRIRALILANWCGFLG---DFSTIFAGSLTSFSISRFISGLAADANSYLMY 195
            :.|:...|::.|:|||.:.|.   ||..|.   ....|.|.:...::|.:..:|........:..
Worm   158 MIGSFTCGVMADKIGRKKVLF---WCLVLQVVCALLLIVAPTWWIYAILKAGTGFTQPGIYGVAV 219

  Fly   196 ILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAV---WVGHWRIFLACSSVPLLLVTLFYFLV 257
            :|.:|.|....|:  ...|:.:.:  |:||...|||   ::..:|:..|..::|.|:...:|:::
Worm   220 VLGIELVGKKYRS--FIAVIANVF--GVIGGVLLAVMAYFIVDYRLLHASIAIPSLIFITYYWMI 280

  Fly   258 QESAQWLVTRNDVDGAIRRLERVAKINRRQV----ADKDFKDFRIYCEQHYRKDKNQEEHAKLLD 318
            .|||:|||::...|.|...|...|..|::.:    |:|..|...:...:  :||.     ..:.|
Worm   281 HESARWLVSQEKYDDANVVLCATANWNKKTIPKNWAEKIEKKMDVTATK--KKDS-----FGVFD 338

  Fly   319 MLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMG 383
            :::||:||.......:::.:....|..:....:..|.|.|:.|..:.|...|:..:..||.||:|
Worm   339 LIRTPQMRKRTIANFVMWPVTTMMYYGLTMRSDVGGGSLFVTFVTSQLMELPAVIIVALLIDRLG 403

  Fly   384 RKATAVGWMAITGIFAVAA----GLVISQGSNRNVLLLVGLTMAARFGVSIADGASSQFSTELIP 444
            |:....|.:...|:..:|:    .|:.||.:   |::|    |.|:..||:|......:::||.|
Worm   404 RRIMYSGAIFTAGMLLLASWLTHDLIPSQYA---VIML----MVAKGAVSVAYTVMYTYTSELFP 461

  Fly   445 TSVRGRGV----AVVHVAGFAASFLSPYIL-HLGTYYKPAPSIILGLLFLSGAYVCLLLPETRNK 504
            |.:|...|    .:......:|||::.::: ..|......|..||.|  .:......:||||.|:
Worm   462 TVIRNTAVGCCSTIARFGAISASFIAFFLVDRFGRIVMIIPFTILAL--CASIVSWTMLPETVNQ 524

  Fly   505 KLPMSLAEGE 514
            :||.|::|.|
Worm   525 QLPDSISEVE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	121/514 (24%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	93/390 (24%)
F45E10.2	NP_001022174.1	MFS_SLC22	121..518	CDD:340875	103/440 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010