DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and C06H5.6

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_507509.3	Gene:	C06H5.6 / 180170	WormBaseID:	WBGene00007394	Length:	556	Species:	Caenorhabditis elegans

Alignment Length:	589	Identity:	140/589 - (23%)
Similarity:	244/589 - (41%)	Gaps:	112/589 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMH-YFSQN--VISFV----------PDHWCYHE 52
            :|.:::|...|...|||  :||    .::..|:| .|:.|  ::.|:          ||    .|
Worm    25 LDADKVLTAFGKYGRYQ--MLA----YVITTSVHMLFALNMMIMPFITKSVEFLCDLPD----PE 79

  Fly    53 QLENRSFAEIEKIYSQFEKPSCTRLEKIDEDGQNHTLSRERCNRWIYKYDFGYKS-MNTELNWVC 116
            .:::..|       |.....||    .:.:...|.|:.....|...|.|....|| :.::.:.||
Worm    80 SIDSAHF-------SPLVGDSC----HLQDTQLNITIDCLAVNGASYNYLADKKSTITSDFDLVC 133

  Fly   117 DEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSISRF 181
            :....|....|:|.||.:..:.....|.|.:||....::..:.....:.....|.:...|.:.||
Worm   134 EYQGMAEHATSIFLVGGMIVSPFVSQLSDILGRRPLFLIPLYISVAANLICAAAPNYLIFLLFRF 198

  Fly   182 ISGLAADANSYLMYILILEYVSPSLRN----------VGLNTVLGSFYCLGLIGACWLAVWVGHW 236
            |||:|..:.|...::|.:|.||...|:          ||...:.|.||           |:..:|
Worm   199 ISGVATTSFSMTGFVLCMESVSLEFRSLIPVLTTISWVGGYMLAGVFY-----------VFFKNW 252

  Fly   237 RIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRL--ERVAKINRRQVADKDFKDFRIY 299
            |:....:|||.||...|::...||..||:|:.: |..|::.  |.|| .|::.::..|.::.:..
Worm   253 RVLYFAASVPGLLTIPFFWFTPESLHWLMTKQN-DRKIKKYINESVA-FNKQTISLIDCRNIQTV 315

  Fly   300 CEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLI------FIIIV--------PCYNTIARNV 350
                        ::|..  ..||...|:..:..:.:      ||:||        ..|:|.....
Worm   316 ------------DNAPA--TTKTRTFRALFYPKIFVHVVINSFILIVMSGTYWALSLYSTELSED 366

  Fly   351 EGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVL 415
            |..|      :.|:.|...|:|:|...|.....||..:...:|.|.:|.:....:..||:.:.:.
Worm   367 ETTG------YFLSGLVELPAGFLSVFLLIAFKRKTVSFYSLAFTAVFMLCTVYIPMQGNYKMIF 425

  Fly   416 LLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAP 480
            .|:     |:...||...:.....:|..||::|.....||...|...|..:||:..|....:.||
Worm   426 PLL-----AKSTNSIVWASQPLLYSEATPTTIRNVFSGVVSFVGELGSIGAPYMNRLTAINQDAP 485

  Fly   481 SIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSKSEVEMGPTI 545
            :|::.::.:..|::.||.|||:|||||..|   ::|..|.        :||  |.|.:.::..:.
Worm   486 AILISIMSIVAAFLVLLQPETKNKKLPEDL---DQFDAGP--------LFR--GWKKQKDLEASE 537

  Fly   546 VEED 549
            ..|:
Worm   538 ASEE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	128/535 (24%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	94/397 (24%)
C06H5.6	NP_507509.3	MFS_SLC22	115..504	CDD:340875	101/426 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010