DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14855 and SLC22A9

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_543142.2	Gene:	SLC22A9 / 114571	HGNCID:	16261	Length:	553	Species:	Homo sapiens

Alignment Length:	551	Identity:	131/551 - (23%)
Similarity:	230/551 - (41%)	Gaps:	72/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIE-- 63
            |.|:::|...|:..|:|.:.........|...:|:..:|..:|:|.|.|:...|:|.:.::.:
Human     1 MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTG 65

  Fly    64 ------------KIYSQFEKPSCTRL-----EKIDEDG---QNHTLSRERC-NRWIYKYDFGYKS 107
                        .:.|......|.|.     :.:..:|   .......|.| :.|:|.......:
Human    66 ALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSST 130

  Fly   108 MNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWC----GFLGDFSTI 168
            :.||.:.|||......|.:.:|..|.:.|.:..|.|.||.||   ..:..||    ..:|..:.:
Human   131 IVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGR---RFVLRWCYLQVAIVGTCAAL 192

  Fly   169 FAGSLTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGAC------ 227
             |.:...:...||:||:||.:......:||.|:.:...:.:|:.           :|.|
Human   193 -APTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGIT-----------LGMCPSGIAF 245

  Fly   228 ----WLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQV 288
                .||..:..|.|.....|||..::.|....:.|||:||:..|..:..::.|.:.|..:..:.
Human   246 MTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKN 310

  Fly   289 ADKDFKDFRIYCEQHYRKDKN--QEEHAKLLDMLKTP----RMRSTAFKLLLIFIIIVPCYNTIA 347
            | :|.....| .:...:|:..  |::...|.:||..|    |:...:|.....|:    .|..:.
Human   311 A-RDTLTLEI-LKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFM----AYFGLN 369

  Fly   348 RNVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSN- 411
            .:|:.||.:.|::.:|....:..:..:.......|.|:|:.:..|.:..|..:|...|..:...
Human   370 LHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTL 434

  Fly   412 RNVLLLVGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYY 476
            |.||..:||..:|     :|:..:.....|:|||.:|.|.:.:.......|..|:|.::.|..|.
Human   435 REVLATLGLGASA-----LANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYS 494

  Fly   477 KPAPSIILGLL-FLSGAYVCLLLPETRNKKL 506
            .|.|.||.|:. |:|| :..|||||||||.|
Human   495 PPLPWIIYGVFPFISG-FAFLLLPETRNKPL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	128/541 (24%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	94/393 (24%)
SLC22A9	NP_543142.2	Sugar_tr	11..527	CDD:331684	128/541 (24%)
SLC22A9	NP_543142.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153764
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940