DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_659105.2	Gene:	Slc22a7 / 108114	MGIID:	1859559	Length:	540	Species:	Mus musculus

Alignment Length:	558	Identity:	132/558 - (23%)
Similarity:	249/558 - (44%)	Gaps:	68/558 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQ---FVLLALYGYLMVVVSMHYFSQNVISFVPDHWC---------YHEQ 53
            |.|||:|.|.|....:|   .|||||..:|:   .||:.....::.||.|.|         .|:.
Mouse     1 MGFEELLHKVGGFGPFQLRNLVLLALPRFLL---PMHFLLPIFMAAVPAHHCALPDAPANLSHQD 62

  Fly    54 L---------ENRSFAEIEKIYSQFEKPSCTRLEKI----DEDGQNHTLSRERCNR-WIYKYDFG 104
            |         .:.||:...:.......|:.|...::    :.:|:..|:.   |:: |.|.....
Mouse    63 LWLKTHLPRETDGSFSSCLRFAYPQALPNVTLGTEVYNSGEPEGEPLTVP---CSQGWEYDRSEF 124

  Fly   105 YKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIF 169
            ..::.||.:.||.:....:|..:.||:|.:.|.:.:|.|.||.||.|.|::|.       .||:.
Mouse   125 SSTIATEWDLVCQQRGLNKVTSTCFFIGVLLGAVVYGYLSDRFGRRRLLLVAY-------VSTLA 182

  Fly   170 AGSLTSFSI-------SRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGAC 227
            .|.:::.|:       :|.::|.|....:.::..|.||::....|.|. ..:..:|:..|::...
Mouse   183 LGLMSAASVNYIMFVTTRMLTGSALAGFTIIVLPLELEWLDVEHRTVA-GVISTTFWTGGVLLLT 246

  Fly   228 WLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKD 292
            .:...:..||..|..:::|.:...:..:.|.|||:||:|:..|:.|.:.|...||:|.|.:::..
Mouse   247 LVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLSICAKLNGRPISEDS 311

  Fly   293 FKDFRIYCEQHYRKDKNQE---EHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLG 354
            ..      ::...|....|   :....||:.:|.::|..:...::::..:...|..:..:..|||
Mouse   312 LS------QEALNKVITMERVSQRPSYLDLFRTSQLRHVSLCCMMMWFGVNFSYYGLTLDASGLG 370

  Fly   355 ISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGI-FAVAAGLVISQGSNRNVLLLV 418
            ::.:....|......||......|...:||:.|..|.:..|.: |.::  |::|..:...:..||
Mouse   371 LTVYQTQLLFGAVEVPSKITVFFLVRLVGRRLTEAGMLLATALTFGIS--LLVSSDTKSWITALV 433

  Fly   419 GLTMAARFGVSIADGASSQ---FSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAP 480
            .:      |.:.::.|.:.   |::||.||.:|..|:....:.|...:.|:|.::.|...:...|
Mouse   434 VI------GKAFSEAAFTTAYLFTSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDGVWLLLP 492

  Fly   481 SIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGR 518
            .:..|.:....|...||||||:..:||.::.:.|..||
Mouse   493 KLAYGGISFLAACTVLLLPETKKAQLPETIQDVERKGR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	121/535 (23%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	87/385 (23%)
Slc22a7	NP_659105.2	2A0119	11..521	CDD:273328	123/537 (23%)
Slc22a7	NP_659105.2	MFS	146..511	CDD:119392	87/386 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950