DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14855 and slc22a5

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_002934410.2	Gene:	slc22a5 / 100486941	XenbaseID:	XB-GENE-484416	Length:	550	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	139/565 - (24%)
Similarity:	239/565 - (42%)	Gaps:	65/565 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIEKIY 66
            |:::..|..|....:|..:..|....::.......|...::..|:|.|:..:..|.|.|
Frog     3 DYDQATAFLGEWGPFQVSVFFLLSASIIPNGFTGLSAVFLAATPEHRCHIPESANLSAA------ 61

  Fly    67 SQFEKPSCTRLEKIDEDGQ-------------NHT--------------LSRERC-NRWIYKYDF 103
              :...|..|     :|||             |::              :.:|.| :.|.|....
Frog    62 --WRNASIPR-----QDGQDSQCRRYRLGTLTNYSALGLLPGRDVDVTGIEQEPCLDGWNYSKSL 119

  Fly   104 GYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALI--LANWCGFLGDFS 166
            ...::.||.|.||:..:|..:..||||||.:.|:...|.:.||.||.:.|.  :|...||  ...
Frog   120 YLSTIVTEWNLVCENDWKGPLTTSLFFVGVLIGSFVSGQMSDRFGRKKVLFATMAVQTGF--SII 182

  Fly   167 TIFAGSLTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGACWLAV 231
            .:|:.:...|:....|.|:...:|....:||..|.:..|:|.:.....:..||.:|.:.....|.
Frog   183 QVFSVNWEMFTALFIIVGMGQISNYVAAFILGAEILDKSVRIIFSTLGVCIFYAIGYMLLPLFAY 247

  Fly   232 WVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDF 296
            ::..||..|...::|.|.....::::.||.:||:::.....|...:.:.||.|.....|..|.
Frog   248 FIRDWRTLLLALTIPGLFCIPLWWIIPESPRWLISQGRFQEAEDIIRKAAKKNGITPPDSIFN-- 310

  Fly   297 RIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMF 361
              :.|...:|:...:.|. .||:|||..:|...|..:|:::||...|..::.|...|...|::..
Frog   311 --FTELQEQKELTHKSHT-FLDLLKTRNIRIITFLSILLWMIISVGYFGLSLNTPNLHGDPYVNC 372

  Fly   362 SLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLVISQGSNRNVLLLVGLTMAARF 426
            .|:|:...|:..:..||.....|:.:....:.:.|:..:...||..:..    :|.:.|.|..:|
Frog   373 FLSAIIEVPAYVIAWLLLRSFPRRYSTASTLVLGGVVLLFIQLVPQELG----ILSIVLVMLGKF 433

  Fly   427 GVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSG 491
            |::.|......::.||.||.||..||....:|....|.||||.::||.|.:..|.|::|.|.:..
Frog   434 GITSAFSMVYVYTAELYPTVVRNMGVGASSMASRMGSILSPYFVYLGAYDRFLPFILMGSLTVLI 498

  Fly   492 AYVCLLLPETRNKKLPMSLAEGEEFGRGEGIFDFLRHMFRREGSK 536
            ....|.|||:....||.::   ||..|.:|        ||.:..|
Frog   499 GMFTLCLPESHGMPLPDTI---EEMLRVKG--------FRYKAGK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	128/525 (24%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	99/373 (27%)
slc22a5	XP_002934410.2	2A0119	12..516	CDD:273328	130/527 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100