DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14855 and si:dkey-166k12.1

DIOPT Version :9

Sequence 1:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_001341287.1	Gene:	si:dkey-166k12.1 / 100001249	ZFINID:	ZDB-GENE-120215-78	Length:	537	Species:	Danio rerio

Alignment Length:	545	Identity:	127/545 - (23%)
Similarity:	221/545 - (40%)	Gaps:	71/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFEEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFVPDH-----------WCYHEQL 54
            |:|:::||..|...:||.:|........:.:..|..:.......|.|           |.:...|
Zfish     1 MNFDQLLATIGGFGKYQKLLYVWICLPQIFLGFHMMASVFTGATPPHRCRGSTSGMEDWTFTSNL 65

  Fly    55 E--NRSFAEIEKIYSQFEKPSCTRLEKIDEDGQNHTLSRERCNR-WIYKYDFGYKSMNTELNWVC 116
            .  |.|.:.:...     ..:||....::..      :|..|.. |:|.::....:..||.:.||
Zfish    66 SHVNLSISRLAGF-----ADACTAASGVNRS------ARTNCETGWVYSHEVFQSTTVTEWDLVC 119

  Fly   117 DEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFSISRF 181
            |:...:.:|.|::.:|.:.|.:.||.:.||.||..|::::.....:...:..||.:...:...||
Zfish   120 DKRGLSSLGSSIYMLGLLVGAVVFGAMADRYGRRFAMLVSLALQTVFGVAAAFAPNFPVYVGLRF 184

  Fly   182 ISGLAADANSYLMYILILEYVSPSLRNV-GLNTVLGSFYCLGLIGACWLAVWVGHWRIFLACSSV 245
            |.|:.........::|..|:.....|.: |:.|  ..|:..|.:....:|..:..||......|.
Zfish   185 IIGMTVSGVIINAFVLGTEWTCTQRRMLAGIFT--DYFFGFGYMLLAGVAFLIRDWRKLQLAISA 247

  Fly   246 PLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRR------QVADKDFKDFRIYCEQHY 304
            |..|...:.:::..||:||:..|..:.||..|.:.|.:|.|      ||             :.|
Zfish   248 PGFLFIFYIWVLPHSARWLLVNNRKEEAIDLLRKAASVNGRTLPPTVQV-------------ERY 299

  Fly   305 RKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFI-MFSLNALTL 368
            ...:.:.::. ::|:|:||:||..|..|..|:.:.|..|..::..|..||...:: .|....:.:
Zfish   300 ESPQGRSKYT-VVDLLRTPQMRKRALILFYIWFVNVLVYYGLSLGVSDLGADLYLTQFMFGLVEI 363

  Fly   369 PPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAG--------LVISQGSNRNVLLLVGLTMAAR 425
            |....:..||.  ..||..       ..:|.|..|        |.......|..|.:||     :
Zfish   364 PARTLVLVLLP--CSRKIP-------LSVFLVVGGGACLLTLTLPADSAHVRTALAMVG-----K 414

  Fly   426 FGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLS 490
            ||::.:......:|.||.||.:|..|:.|..:.......|:|.|..||.:....|.:|.|...|.
Zfish   415 FGITASFAIIYVYSAELFPTVLRQTGIGVSSMFARMGGVLAPLINLLGRHTPVVPMLIFGSTPLL 479

  Fly   491 GAYVCLLLPETRNKKLPMSLAEGEE 515
            .|.:.|.||||..:.||.|:.:.|:
Zfish   480 AAALALALPETARQPLPDSIHDTEK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	119/525 (23%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	92/387 (24%)
si:dkey-166k12.1	XP_001341287.1	2A0119	11..497	CDD:273328	120/526 (23%)
si:dkey-166k12.1	XP_001341287.1	MFS	123..458	CDD:119392	84/364 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950