DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7362 and PKLR

DIOPT Version :9

Sequence 1:	NP_650388.2	Gene:	CG7362 / 41787	FlyBaseID:	FBgn0038258	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_000289.1	Gene:	PKLR / 5313	HGNCID:	9020	Length:	574	Species:	Homo sapiens

Alignment Length:	456	Identity:	161/456 - (35%)
Similarity:	225/456 - (49%)	Gaps:	99/456 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LDYQSRLQFQAPALRLPLTSIICTIGPSSSQPEVLLNLIHAGMKVVRLDFSDGTHDCHCQAIQAA 81
            |::...|...:..:....||||.||||:|...|.|..:|.|||.:.||:||.|:|:.|.::|...
Human    70 LEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANV 134

  Fly    82 RKAIAMYAEETGLP---RSLAIALDTKGPVI---------------------------------- 109
            |:|:..:|   |.|   |.:|||||||||.|
Human   135 REAVESFA---GSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGN 196

  Fly   110 --------------------------------------------------------NPQGVAADL 118
                                                                    |..|...||
Human   197 ANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDL 261

  Fly   119 NAITEQDKLDLKFGADQKVDMIFASFIRDAKALKEIRQALGACPSSEHIKIISKIESQQALANID 183
            ..::|||..||:||.:..||::||||:|.|..:..:|.|||  |....||||||||:.:.:...|
Human   262 PGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALG--PEGHGIKIISKIENHEGVKRFD 324

  Fly   184 EIIRESDGIMVALGNMGNEIALEAVPLAQKSIVAKCNKVGKPVICANQMMNSMITKPRPTRAESS 248
            ||:..|||||||.|::|.||..|.|.||||.::.:||..||||:||.||:.||||||||||||:|
Human   325 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETS 389

  Fly   249 DVANAILDGCDALVLSDETAKGKYPVQCVQCMARICAKVESVLWYESIQNNLKSEVRINAADHIS 313
            |||||:|||.|.::||.|||||.:||:.|:....|..:.|:.:::..:...|:....: :.|...
Human   390 DVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPL-SRDPTE 453

  Fly   314 AVSTAIAEAATVSQAQAIVVASPCSIVSQMVSQMRPPCPIVLLTGCPHEAAQSLLFRGVYPLLVK 378
            ..:....|||....|.||:|.:.....:|::|:.||...::.:|.....|.|..|.|||:|||.:
Human   454 VTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYR 518

  Fly   379 E 379
            |
Human   519 E 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7362	NP_650388.2	Pyruvate_Kinase	35..407	CDD:304951	159/438 (36%)
CG7362	NP_650388.2	pyruv_kin	35..391	CDD:273424	159/438 (36%)
PKLR	NP_000289.1	Pyruvate_Kinase	85..573	CDD:238178	159/441 (36%)
		Fructose-1,6-bisphosphate binding, allosteric activator. /evidence=ECO:0000269\|PubMed:11960989, ECO:0007744\|PDB:2VGF	475..480		0/4 (0%)
		Fructose-1,6-bisphosphate binding, allosteric activator. /evidence=ECO:0000269\|PubMed:11960989, ECO:0007744\|PDB:2VGF	559..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.780