DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7362 and pyk1

DIOPT Version :9

Sequence 1:	NP_650388.2	Gene:	CG7362 / 41787	FlyBaseID:	FBgn0038258	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_594346.1	Gene:	pyk1 / 2543557	PomBaseID:	SPAC4H3.10c	Length:	509	Species:	Schizosaccharomyces pombe

Alignment Length:	494	Identity:	188/494 - (38%)
Similarity:	243/494 - (49%)	Gaps:	117/494 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TSIICTIGPSSSQPEVLLNLIHAGMKVVRLDFSDGTHDCHCQAIQAARKAIAMYAEETGLPRSLA 99
            |||||||||.|:..|.|..|..|||.:||::||.|:::.|...|..||||.|     |.....||
pombe    28 TSIICTIGPKSNNVETLCKLRDAGMNIVRMNFSHGSYEYHQSVIDNARKASA-----TNPLFPLA 87

  Fly   100 IALDTKGP-----------------------------------------------VINP------ 111
            ||||||||                                               ||.|
pombe    88 IALDTKGPEIRTGLTVGGTDYPISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVIQPGRIIYV 152

  Fly   112 -------------------------------QGV-----AADLNAITEQDKLDLKFGADQKVDMI 140
                                           :||     ..||.|::|:||.||:||....||||
pombe   153 DDGILSFTVIEKVDDKNLKVRVNNNGKISSKKGVNLPKTDVDLPALSEKDKADLRFGVKNGVDMI 217

  Fly   141 FASFIRDAKALKEIRQALGACPSSEHIKIISKIESQQALANIDEIIRESDGIMVALGNMGNEIAL 205
            ||||||.|:.:..||:.||  ...::||||.|||:||.:.|.|.|:..:||||||.|::|.||..
pombe   218 FASFIRRAEDVIHIREVLG--EEGKNIKIICKIENQQGVNNFDSILDVTDGIMVARGDLGIEIPA 280

  Fly   206 EAVPLAQKSIVAKCNKVGKPVICANQMMNSMITKPRPTRAESSDVANAILDGCDALVLSDETAKG 270
            ..|.:|||.::||||..||||.||.||:.||...|||||||.|||.||:|||.|.::||.||.||
pombe   281 SQVFVAQKMMIAKCNIAGKPVACATQMLESMTYNPRPTRAEVSDVGNAVLDGADLVMLSGETTKG 345

  Fly   271 KYPVQCVQCMARICAKVESVLWYESIQNNLKSEVR--INAADHISAVSTAIAEAATVSQAQAIVV 333
            .|||:.|..||......|:.:.|.|:...:...||  :..|...:||  |...|:..|.|:||||
pombe   346 SYPVEAVTYMAETARVAEASIPYGSLYQEMFGLVRRPLECATETTAV--AAIGASIESDAKAIVV 408

  Fly   334 ASPCSIVSQMVSQMRPPCPIVLLTGCPHEAAQSLLFRGVYPLLVKEM--------VYGSVNYCRI 390
            .|.....:::.|:.||..|||::|.||..|.||.|.|||||::.::.        |...|.|
pombe   409 LSTSGNTARLCSKYRPSIPIVMVTRCPQRARQSHLNRGVYPVIYEKEPLSDWQKDVDARVAY--- 470

  Fly   391 MQSGLKILAKLDILKAGQRGTLVLVNAMSADKLT--FRL 427
               |.:...|::|||.|.: .:||..|:.....|  |||
pombe   471 ---GCQQAYKMNILKKGDK-IIVLQGAVGGKGHTSIFRL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7362	NP_650388.2	Pyruvate_Kinase	35..407	CDD:304951	180/470 (38%)
CG7362	NP_650388.2	pyruv_kin	35..391	CDD:273424	175/454 (39%)
pyk1	NP_594346.1	Pyruvate_Kinase	25..508	CDD:238178	188/494 (38%)
pyk1	NP_594346.1	pyruv_kin	26..505	CDD:273424	186/492 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.770