DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smp-30 and RGN

DIOPT Version :9

Sequence 1:	NP_001262580.1	Gene:	smp-30 / 41786	FlyBaseID:	FBgn0038257	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_004674.1	Gene:	RGN / 9104	HGNCID:	9989	Length:	299	Species:	Homo sapiens

Alignment Length:	310	Identity:	107/310 - (34%)
Similarity:	157/310 - (50%)	Gaps:	26/310 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SYKVEAVPDSYAALGEGPHWDVDRQSLYYVDLESAGINRYDFKQNKVYRAKIEGEIFASFILPVE 69
            |.|:|.|.......||.|.|:....||.:||:.:..:.|:|....:|.|..::..: :|..|
Human     3 SIKIECVLPENCRCGESPVWEEVSNSLLFVDIPAKKVCRWDSFTKQVQRVTMDAPV-SSVAL--- 63

  Fly    70 NKPQEFAVGCGLRTVIVQWDGVSAVAKVTRTLFEVQPDLKENRLNDAKTDPNGRFYGGTMAD--S 132
            .:...:....|.:...:.|...|||...|     |..|.|.||.||.|.||.||::.||||:  :
Human    64 RQSGGYVATIGTKFCALNWKEQSAVVLAT-----VDNDKKNNRFNDGKVDPAGRYFAGTMAEETA 123

  Fly   133 GDIFTQWKGELYSWQAGGQPNAIRSKVGISNGLAWDVKAKKFYFIDTNNHEVLAYDYNQSTGAVS 197
            ..:..:.:|.|||............:|.|||||.|.:..|.||:||:.::.|.|:||:..||.:|
Human   124 PAVLERHQGALYSLFPDHHVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYSVDAFDYDLQTGQIS 188

  Fly   198 NPKVIFDLRKIRPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPSTGKILLEIKIPTTQITSVA 262
            |.:.::.|.|...    .||||.:|.:|.::||.:|||.|.:::|.|||.|..:|:|..:.||..
Human   189 NRRSVYKLEKEEQ----IPDGMCIDAEGKLWVACYNGGRVIRLDPVTGKRLQTVKLPVDKTTSCC 249

  Fly   263 FGGPNLDILYVTTANKFDQPK------PAGTTFQVTGLNAKG-----YAG 301
            |||.|...:|||.|.....|:      .||..|::|||..||     |||
Human   250 FGGKNYSEMYVTCARDGMDPEGLLRQPEAGGIFKITGLGVKGIAPYSYAG 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smp-30	NP_001262580.1	SGL	18..277	CDD:285626	90/260 (35%)
		NHL	168..>248	CDD:302697	31/79 (39%)
		NHL repeat	168..208	CDD:271320	14/39 (36%)
RGN	NP_004674.1	SGL	16..264	CDD:400653	90/260 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141112
Domainoid	1	1.000	154	1.000	Domainoid score	I4262
eggNOG	1	0.900	-	-		E1_COG3386
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3437
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4119
Isobase	1	0.950	-	0	Normalized mean entropy	S4948
OMA	1	1.010	-	-		QHG61138
OrthoDB	1	1.010	-	-		D1343872at2759
OrthoFinder	1	1.000	-	-		FOG0003598
OrthoInspector	1	1.000	-	-		otm41117
orthoMCL	1	0.900	-	-		OOG6_101744
Panther	1	1.100	-	-	O	PTHR10907
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2337
SonicParanoid	1	1.000	-	-		X2470
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750