DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smp-30 and rgn

DIOPT Version :9

Sequence 1:	NP_001262580.1	Gene:	smp-30 / 41786	FlyBaseID:	FBgn0038257	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_991309.1	Gene:	rgn / 403070	ZFINID:	ZDB-GENE-040718-68	Length:	295	Species:	Danio rerio

Alignment Length:	331	Identity:	114/331 - (34%)
Similarity:	161/331 - (48%)	Gaps:	72/331 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SYKVEAVPDSYAALGEGPHWDVDRQSLYYVDLESAGINRYDFKQNKVYRAKIEGEIFASFILPVE 69
            |.|||.|......:||.|.|:....||.|||:....::|:                 :|....:|
Zfish     3 SIKVECVIKEKNEVGESPVWEEKDSSLLYVDITGQKVSRW-----------------SSLTKQIE 50

  Fly    70 NKPQEFAVGC-------------GLRTVIVQW--DGVSAVAKVTRTLFEVQPDLKENRLNDAKTD 119
            :...|..|||             |.|...|.|  ..::|||:|..     :|:   .|.||.|.|
Zfish    51 SMNTEKLVGCVVPRQAGGYVIAEGTRFAFVDWVKRSITAVAEVNE-----KPN---TRFNDGKVD 107

  Fly   120 PNGRFYGGTMA-----DSGDIFTQWKGELYSWQAGGQPNAIR--SKVGISNGLAWDVKAKKFYFI 177
            |.|||:.|||:     |..|      ..||:.|.  ..:.:|  .:|.:||||.|.:..:.||:|
Zfish   108 PAGRFFAGTMSMDMKPDVVD------AALYNLQP--DHSVVRHFDQVHLSNGLDWSLDHRVFYYI 164

  Fly   178 DTNNHEVLAYDYNQSTGAVSNPKVIFDLRKIRPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNP 242
            |:....|.|:||:..||.:||.:.::.:.|  .||  .||||.:||:|.::||.||||.|.:::|
Zfish   165 DSLAFMVEAFDYDIQTGGLSNRRTVYKMEK--DEG--IPDGMCIDTEGKLWVACFNGGRVLRIDP 225

  Fly   243 STGKILLEIKIPTTQITSVAFGGPNLDILYVTTA-------NKFDQPKPAGTTFQVTGLNAKG-- 298
            .|||.|..:|:|..:|||..|||.:...||:|:|       ....||: ||.||:||||..||
Zfish   226 QTGKRLQTVKLPAERITSCCFGGKDYSDLYITSAYIGMDAEALAKQPE-AGCTFKVTGLGVKGIP 289

  Fly   299 ---YAG 301
               |.|
Zfish   290 PYSYTG 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smp-30	NP_001262580.1	SGL	18..277	CDD:285626	95/287 (33%)
		NHL	168..>248	CDD:302697	33/79 (42%)
		NHL repeat	168..208	CDD:271320	12/39 (31%)
rgn	NP_991309.1	SGL	16..260	CDD:285626	94/280 (34%)
		NHL	150..>233	CDD:302697	38/86 (44%)
		NHL repeat	150..193	CDD:271320	16/42 (38%)
		NHL repeat	199..233	CDD:271320	19/33 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573987
Domainoid	1	1.000	154	1.000	Domainoid score	I4216
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3437
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4127
OMA	1	1.010	-	-		QHG61138
OrthoDB	1	1.010	-	-		D1343872at2759
OrthoFinder	1	1.000	-	-		FOG0003598
OrthoInspector	1	1.000	-	-		otm26199
orthoMCL	1	0.900	-	-		OOG6_101744
Panther	1	1.100	-	-	O	PTHR10907
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2337
SonicParanoid	1	1.000	-	-		X2470
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940