DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Magi3

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001152826.1	Gene:	Magi3 / 99470	MGIID:	1923484	Length:	1476	Species:	Mus musculus

Alignment Length:	1374	Identity:	271/1374 - (19%)
Similarity:	428/1374 - (31%)	Gaps:	468/1374 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYY 119
            |||..|::|....|..|:|||..|.|||||||.| .|.:..|||...|||.|||:..||..|.||
Mouse   297 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLC-KKAKAPEDCEDGELPYGWEKIEDPQYGTYY 360

  Fly   120 INHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAAS 184
            ::||.|.||.|:|.:|.|. ::|:....:.:|:..:|......|..|            ||....
Mouse   361 VDHLNQKTQFENPVEEAKR-KKQLGQAEIHSAKTDVERAHFTRDPSQ------------LKGVLV 412

  Fly   185 RSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARE 249
            |:||..|:...         ...::..:|    ..|...:.|.:.......:...:.|:.|....
Mouse   413 RASLKKSTMGF---------GFTIIGGDR----PDEFLQVKNVLKDGPAAQDGKIAPGDVIVDIN 464

  Fly   250 NGCYDIAEVHAIREEMLK-------VHKSLVSGEKVREELMRSLVQI-------------KNEL- 293
            ..|. :...||...:|.:       |:.:|..|..:.::....:|.|             |.|.
Mouse   465 GNCV-LGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETC 528

  Fly   294 -----------------------------GRQQISEENSDLASPFDRVCVASQTDLC------GS 323
                                         |..:.||:.:.|||     ..:||.:|.      |.
Mouse   529 MNTQDFKLGAMVLDQNGKSGQILASDRLNGPSESSEQRASLAS-----SGSSQPELVTIPLIKGP 588

  Fly   324 SG-----ENLNGGARFAEMAKTKW----QYAEWRKHIKKLQQQLADHVERIEP-GQLESDKDRIL 378
            .|     .:...|.:...:..::|    |..:..|.|.....|...|::.:|. .|.....|..|
Mouse   589 KGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPL 653

  Fly   379 LI----------QEKEKLLNDLNSISLKSRSEE-------EKRVIHQTRHKLEEDLKEAYEANNT 426
            ||          ..|.|.....||.||::.:|.       ...:|.....||  |..|.|..:.|
Mouse   654 LILRGGPCSPTKTAKTKTDTKENSGSLETINEPIPQPMPFPPSIIRSGSPKL--DPSEVYLKSKT 716

  Fly   427 CVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSS------LGS---LSTA 482
                   .:|:|.          .:||.|:..|:...|...|.:..|..      :|:   |..|
Mouse   717 -------LYEDKP----------PNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAA 764

  Fly   483 SSKSALSFTD--IYID--PFAVDSPIDVVDL--------------RRR-----------SQRLFQ 518
            .....|...|  :.||  |....|...|:||              ||:           |.:.|.
Mouse   765 EKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESHQAFS 829

  Fly   519 QHQQQRLHPVH-PVLQQQQSA-EVTLSPR----------SSLSMETPPASPMKYNAGADQTPQ-- 569
            |:...||:... |.....|.| :|||..:          :|.|...|...|.|.....|.:|.
Mouse   830 QNGSPRLNRAELPTRSAPQEAYDVTLQRKENEGFGFVILTSKSKPPPGVIPHKIGRVIDGSPADR 894

  Fly   570 --ALKEEPTYANALPAPPAYTAPPPVPISGVRARP-YDLDSTVLDCMMLEAKLQKLNMGTPLNLA 631
              .||...                  .||.|..:. .||....:..::.:|       |..:.|.
Mouse   895 CGGLKVGD------------------HISAVNGQSIVDLSHDNIVQLIKDA-------GVTVTLT 934

  Fly   632 VAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFE--------------- 681
            |.........||..:     .:|.|.....|.:..|.:|. :.||....|
Mouse   935 VVAEEEHHGPPSGTN-----SARQSPALQHRPMGQAQANH-IPGDRIALEGEIGRDVCSSYRHSW 993

  Fly   682 ASRAHLPRKELAQVQ-IGLKYLKQEGVLVVSLERA------------------------------ 715
            :...||.:.:.|.:. :|.::.:..|...|.|||.
Mouse   994 SDHKHLAQPDTAVISVVGSRHNQSLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAI 1058

  Fly   716 ------------------------NNLLALWTASADNSQVYLR--AALLP-------NSLTSIRT 747
                                    ...:.|..|..:...:.||  ..|:|       ||.:|  :
Mouse  1059 KDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDTNSPSS--S 1121

  Fly   748 KALGDFQKP---------VFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNP 803
            ..:.|.|.|         .|.::. ||.|.|.|       |.|.:..:.||:..|||...:..|.
Mouse  1122 NVIYDEQPPPLPSSHSASTFEESH-VPATEDSL-------TRVQICEKAEELKDTVQEKKSTLNG 1178

  Fly   804 EDSTLKWYNV---LSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQT 865
            ....:|:.:|   :|.|        |.|..|.....:.:...|.
Mouse  1179 SQPEMKYQSVHKTMSKK--------DPPRGSGHGEKSRLKGENG--------------------- 1214

  Fly   866 STLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAY 930
              :||.                  |....|:.|.:...:|..|...:.|.||
Mouse  1215 --VTRR------------------GRSASPKKSVNRHSEEHLEKIPRPLKSD------------- 1246

  Fly   931 LQNMKQEFADKETNTDRAYLPEKSRGQSQL-------MDDRPVKRSQTFTP-------------- 974
                     .||.:.||:..|.|...:.:|       .|.....|.::.:|
Mouse  1247 ---------PKEKSRDRSLSPRKGESKGRLTIKAGSGQDPNRKDRGRSSSPKKQQKIGGNSLSNT 1302

  Fly   975 ----SEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSL------RFHSKAP-KSVTKL 1028
                |||.|:....   :..||...:     |...::....|:.|      :..:|:| |..:|:
Mouse  1303 EGKLSEAGSRRAAG---HPRDSTEQL-----PDGREKSGVSRKDLKQSQPGKTRTKSPEKKSSKV 1359

  Fly  1029 HHTHIP--RTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQR 1091
            ..|.:|  :||                        .....|:.:..:.|.|.....:.|..|..:
Mouse  1360 DETSLPSKKTS------------------------STAGRVVSEKEKGKKPTAGETSRETVEHTQ 1400

  Fly  1092 LVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSE 1156
            :.|:    :..:|.| :|..:..|.: ||.|:::|...|.:......:.:...:|   .|..|..
Mouse  1401 ISAK----QLKQEAQ-EKTALGNADD-HKGRESEVTDRCRERAGCTPQSSSLVKK---APITPGP 1456

  Fly  1157 FTLPEANPI 1165
            :.:|.||.:
Mouse  1457 WRVPRANKV 1465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/29 (52%)
		WW	103..132	CDD:278809	16/28 (57%)
		C2_Kibra	693..813	CDD:176062	34/192 (18%)
Magi3	NP_001152826.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:15652357	18..108
		PDZ_signaling	24..103	CDD:238492
		NK	125..>199	CDD:302627
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266
		WW	297..329	CDD:197736	17/31 (55%)
		WW	345..375	CDD:238122	16/29 (55%)
		Interaction with PTEN. /evidence=ECO:0000250	413..495		15/95 (16%)
		PDZ	416..496	CDD:214570	13/93 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..575		6/28 (21%)
		PDZ	578..659	CDD:214570	16/80 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..691		7/26 (27%)
		PDZ	729..812	CDD:214570	17/82 (21%)
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811		16/81 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..844		6/25 (24%)
		PDZ_signaling	851..936	CDD:238492	20/109 (18%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939		21/111 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..966		5/31 (16%)
		PDZ_signaling	1023..1101	CDD:238492	6/77 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1109..1151		10/44 (23%)
		MIP-T3	<1166..>1431	CDD:287245	63/373 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1168..1476		70/410 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12244
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900