Protein Alignment kibra and AREL1

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001034568.1
• Gene: AREL1 / 9870
• HGNCID: 20363
• Length: 823
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 103/529 - (19%)
• Similarity: 170/529 - (32%)
• Gaps: 168/529 - (31%)

  Fly   764 VPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFE-SLDI 827
            :|:|.:.|...:..|..|..|.:|   .|..:|::        .|...||..|.:...|: .:.:
Human   111 IPVTQEVLQEPNSNVVKVAFTVRK---AGRYEITV--------KLGGLNVAYSPYYKIFQPGMVV 164

  Fly   828 PSTSAAAA--AAAVAASNAP------------NPGNN----REE------------SSDESTITS 862
            ||.:....  :..|.....|            ||.||    |:|            ..:|||..|
Human   165 PSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVS 229

  Fly   863 SQTSTLTRNQA----------------PCMELQEQMAAELLGLGPLNEPE-----CSDDDDDDEE 906
            .:.|..:..|.                .|:..|.|         |:|..|     .|:|:.:..|
Human   230 FEKSVTSNRQTFQVFLRLTLHSRGCFHACISYQNQ---------PINNGEFDIIVLSEDEKNIVE 285

  Fly   907 EELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRA--YLPEKSRGQSQLMDDRPVKRS 969
            ..      ||..|:   |....|||.|        .||....  :||......||......|...
Human   286 RN------VSTSGV---SIYFEAYLYN--------ATNCSSTPWHLPPMHMTSSQRRPSTAVDEE 333

  Fly   970 QTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIP 1034
            ...:|||..:..:..       ....::|.|:|..|                  ||.:.:...||
Human   334 DEDSPSECHTPEKVK-------KPKKVYCYVSPKQF------------------SVKEFYLKIIP 373

  Fly  1035 RTSLDLELDLQAQHSKLYFLN-DQIAKL------QNLKEVLQKACENKDPLVAAWAIE------- 1085
            .......:   ...:|..:|. |.:.||      ..::..::.:|:.::.|.|.:...
Human   374 WRLYTFRV---CPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGG 435

  Fly  1086 NEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSV 1150
            :|.||..|...       :|:|:::.||..   |.....||.:..  |:....|.|    :..|:
Human   436 SETFQDKVNFF-------QRELRQVHMKRP---HSKVTLKVSRHA--LLESSLKAT----RNFSI 484

  Fly  1151 PELPSEFTLPEANPIEEEEEEED----ENEFYNSAETAI--AINTALVASSNRNKNLSEHPHRAT 1209
            .:....|.:     :.::||..|    ..|::.....|:  ..|......|:.|:.| .||:
Human   485 SDWSKNFEV-----VFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPN--- 540

  Fly  1210 SGAVPKIPA 1218
                |..||
Human   541 ----PNRPA 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	10/48 (21%)
AREL1	NP_001034568.1	Filamin	52..158		13/57 (23%)
		Filamin	56..154	CDD:395505	13/53 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..345		7/29 (24%)
		Interaction with SOCS2. /evidence=ECO:0000269|PubMed:31578312	483..789		16/76 (21%)
		HECTc	486..820	CDD:214523	15/73 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900