DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and BAG3

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_004272.2	Gene:	BAG3 / 9531	HGNCID:	939	Length:	575	Species:	Homo sapiens

Alignment Length:	465	Identity:	104/465 - (22%)
Similarity:	165/465 - (35%)	Gaps:	134/465 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 ERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDI---YIDPFAVDSPIDVVD----LRRRSQ 514
            ||.:|.::....|.||.:||.|    |.:|:|....:   ||.       |.|:.    .|..:|
Human   169 ERSQSPAASDCSSSSSSASLPS----SGRSSLGSHQLPRGYIS-------IPVIHEQNVTRPAAQ 222

  Fly   515 RLFQQHQQQRLH------------PVHPVLQ-------------------QQQSAEVTLSPRSSL 548
            ..|  ||.|:.|            ||:..:|                   |..|:......|||.
Human   223 PSF--HQAQKTHYPAQQGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSST 285

  Fly   549 SMETPPASPMKYNAGADQTPQALKEEPTYANALP-----APPAYTAP--PP--VPISGVRARPYD 604
            .:.:|  ||::.:...|:..|.:....|...:.|     :.|....|  ||  :||..:|.   :
Human   286 PLHSP--SPIRVHTVVDRPQQPMTHRETAPVSQPENKPESKPGPVGPELPPGHIPIQVIRK---E 345

  Fly   605 LDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVS 669
            :||..:. .......:|:.:..|  .|..|..|.|..||.  :|.   |..|..:..|:..:...
Human   346 VDSKPVS-QKPPPPSEKVEVKVP--PAPVPCPPPSPGPSA--VPS---SPKSVATEERAAPSTAP 402

  Fly   670 NESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVL--VVSLERANNLLALWTASADN---- 728
            .|:.....|..||...| |         |:  ||.|.:|  |..||:|          .||
Human   403 AEATPPKPGEAEAPPKH-P---------GV--LKVEAILEKVQGLEQA----------VDNFEGK 445

  Fly   729 --------SQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTG 785
                    .:.||...||  :|.|:..:...|.::...:....|...|:||..|::.|.
Human   446 KTDKKYLMIEEYLTKELL--ALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVP------ 502

  Fly   786 QKEEIIGTVQI------SMAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNA 844
                  |.||:      ::....|..:.::...|.:.|...:..:.:.|.|......|..||::.
Human   503 ------GQVQVYELQPSNLEADQPLQAIMEMGAVAADKGKKNAGNAEDPHTETQQPEATAAATSN 561

  Fly   845 PN-----PGN 849
            |:     |||
Human   562 PSSMTDTPGN 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	28/139 (20%)
BAG3	NP_004272.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92
		WW	21..53	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..200		12/34 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..421		42/203 (21%)
		BAG	421..498	CDD:214591	22/90 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..575		10/40 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900