DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kibra and TRIP12

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:XP_024308991.1 Gene:TRIP12 / 9320 HGNCID:12306 Length:2092 Species:Homo sapiens


Alignment Length:1108 Identity:202/1108 - (18%)
Similarity:343/1108 - (30%) Gaps:395/1108 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   204 RADLMLARERVHQLKQELTHITNDISYTERG------MNTLYSVGEKINARENGCYDIAEVHAIR 262
            |.|..:.....||:.::      :||.:..|      .|::..:.|          |.....||:
Human   825 RIDSRIIEVAAHQVGED------EISLSTLGRVYTIDFNSMQQINE----------DTGTARAIQ 873

  Fly   263 EEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSS-GE 326
            .:...:..|..||..          :.|.:..|.|:.:|:.:||..|.:.......::..|| |.
Human   874 RKPNPLANSNTSGYS----------ESKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGP 928

  Fly   327 NLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILL--IQEKEKLLND 389
            .:......|.:....:..||..|.:.| ...::.|:    ...|.|...:|::  :|..|.|:..
Human   929 AVRHKCLRAILRIIYFADAELLKDVLK-NHAVSSHI----ASMLSSQDLKIVVGALQMAEILMQK 988

  Fly   390 LNSI-SLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTK 453
            |..| |:..|.|   .|:||.:|.                       .|.:.||....:|..:  
Human   989 LPDIFSVYFRRE---GVMHQVKHL-----------------------AESESLLTSPPKACTN-- 1025

  Fly   454 LLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQ 518
                  .|.|..||.|:|||:     :||::.:|                   .||.        
Human  1026 ------GSGSMGSTTSVSSGT-----ATAATHAA-------------------ADLG-------- 1052

  Fly   519 QHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPA 583
                      .|.||..:...:.|||:..||                   ..||.:...... |.
Human  1053 ----------SPSLQHSRDDSLDLSPQGRLS-------------------DVLKRKRLPKRG-PR 1087

  Fly   584 PPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLL-DL 647
            .|.|:.|              .|...:|                 |.|.:|.:..|.|.|.| .|
Human  1088 RPKYSPP--------------RDDDKVD-----------------NQAKSPTTTQSPKSSFLASL 1121

  Fly   648 PQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLK---------YLK 703
            ..:...|.|:.||:.::..|    ..||.||:..|:..........:::..:|         |..
Human  1122 NPKTWGRLSTQSNSNNIEPA----RTAGGSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFS 1182

  Fly   704 QEGVLVVSLERAN---NLLALWTASAD--NSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFA 763
            .|     :::.:|   |:|....|:.:  |.||...|..|....:.:....:..|:  :.:..|.
Human  1183 SE-----NMDGSNPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFE--IQHSGFV 1240

  Fly   764 VPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDIP 828
            ..:.|           .:|...:|:.:...:::                   .:|:..|.|..:|
Human  1241 KQLLL-----------YLTSKSEKDAVSREIRL-------------------KRFLHVFFSSPLP 1275

  Fly   829 STSAAAAAAAVAASNAP-----NPGNNREESSDESTIT--------------SSQTSTLTRNQAP 874
            ..........|  .|||     :..||.....::..:.              |........:|..
Human  1276 GEEPIGRVEPV--GNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGRGSQALKFFNTHQLK 1338

  Fly   875 CMELQEQ----------------------MAAE----LLGLGPLNEPECSDDDDDDEEEELDDKQ 913
            | :||..                      .|.|    :.|.|.:.|.: .|.|||..:||:|:..
Human  1339 C-QLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDD-EDSDDDGSDEEIDESL 1401

  Fly   914 L--------------------------VSDVGLMNSSSMLHA---YL------------QNMKQ- 936
            :                          :.....:||.::.|.   |:            |.::| 
Human  1402 VRYYIPTMYNVLYKVQGLWLKWLLLCFIQAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQF 1466

  Fly   937 --EFADKETNTDRAYLPEKSRG---QSQLMDDRPVK---------------RSQTFTPSEAFSKN 981
              :..|:..:||....|....|   ::..:..:||:               |:|| .|::...: 
Human  1467 SIQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQT-APTKTSPR- 1529

  Fly   982 RYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQA 1046
                  |....|...|.||.|     ..:....:......|:::|      ....|||:.|.|:.
Human  1530 ------NAKKHDELWHDGVCP-----SVSNPLEVYLIPTPPENIT------FEDPSLDVILLLRV 1577

  Fly  1047 QHS---KLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEF--QRLVARADPAKCPEERQ 1106
            .|:   ..|:|.|...    .||:                |...||  .:|.|:|:       ||
Human  1578 LHAISRYWYYLYDNAM----CKEI----------------IPTSEFINSKLTAKAN-------RQ 1615

  Fly  1107 LQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEK-----ITFFTRKGLSVPELPSEFTLPEANPIE 1166
            ||..|:.....| ....|::.|.||....|..:     :|.|.|.......|.   |.||.|..:
Human  1616 LQDPLVIMTGNI-PTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLD---TNPEINQSD 1676

  Fly  1167 EEE 1169
            .::
Human  1677 SQD 1679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122
WW 103..132 CDD:278809
C2_Kibra 693..813 CDD:176062 17/133 (13%)
TRIP12XP_024308991.1 SR-25 99..>233 CDD:313680
Arm_3 489..>714 CDD:330530
WWE 808..874 CDD:308464 12/64 (19%)
HECTc 1690..2090 CDD:238033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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