DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and MAGI1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens

Alignment Length:	887	Identity:	176/887 - (19%)
Similarity:	295/887 - (33%)	Gaps:	286/887 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQ-TFEDCVGD------------ELPMG 106
            |||:.|::|...:|:.|:|||..|.|:||||| |..|.| ..|:|..|            |||.|
Human   301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPR-CLNKQQKPLEECEDDEGVHTEELDSELELPAG 364

  Fly   107 WEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLW 171
            ||:..||..|.||::|:.:.||.|:|..|.|  :::.|..  ...|.|.:.:::....:||...|
Human   365 WEKIEDPVYGIYYVDHINRKTQYENPVLEAK--RKKQLEQ--QQQQQQQQQQQQQQQQQQQTEEW 425

  Fly   172 AQEEY--------NHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHI---- 224
            .::..        ||          ..|:...:|..|  |:......| ...:||.:..|.
Human   426 TEDHSALVPPVIPNH----------PPSNPEPAREVP--LQGKPFFTR-NPSELKGKFIHTKLRK 477

  Fly   225 -TNDISYTERG--------------------MNTLYSVGEKINARENGCYDIAEVHAIREEMLKV 268
             :....:|..|                    ::.....|:.|.:..:.|. :...||   :::|:
Human   478 SSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV-LGHTHA---QVVKI 538

  Fly   269 HKSLVSGEKVREELMR-------------SLVQIKNELGRQQI---SEEN--------------- 302
            .:|:..|..|..||.|             |||.....|.::.|   .:|.
Human   539 FQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVN 603

  Fly   303 ----------SDLAS------PFDRVCVASQ-----------------------TDLCGSSGE-- 326
                      :|:||      |.|.|.:||.                       .|..|..|:
Human   604 GMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRV 668

  Fly   327 ----------NLNGGARFAEMAKTKWQYAEWRKHIKKL-QQQLADHVERIEPGQLESDKDRILLI 380
                      .|..|....|:.|         |:::.| ..|:.|.:.....|      ..:.|:
Human   669 KQIVDSPRCRGLKEGDLIVEVNK---------KNVQALTHNQVVDMLVECPKG------SEVTLL 718

  Fly   381 QEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKL--EEDLKEAYEANNTCVANRLRFHEEK----- 438
            .::..|  .:...|.||:..|.|...:.::|.:  ...|..|..:::|.|.......|.:
Human   719 VQRGGL--PVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQT 781

  Fly   439 ----QLLLDKLQEALKSTKLLEERLKSFSSEST----------FSISSGSSLGS---------LS 480
                |...|..:...:|..:.|.||..:..:..          |.|..|:..|.         |.
Human   782 DSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLG 846

  Fly   481 TASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPR 545
            .|.:...|...|..|       .:|...:..:|.:|..|..||.....|..|..::.. |...|:
Human   847 AADTDGRLRSGDELI-------CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV-VFAVPK 903

  Fly   546 SSLSMETPPASPMKYNAGAD-----QTPQALKEEPTYANALPAPPAYTAPPPVPISGVRA----- 600
            :...:.:|.:|....|..|.     :|||..:..   .|.:.:....|       ||:.:
Human   904 TENEVPSPASSHHSSNQPASLTEEKRTPQGSQNS---LNTVSSGSGST-------SGIGSGGGGG 958

  Fly   601 --------RPYDLD--------------STVL----------DCMMLEAKLQKLNMGTPLN---- 629
                    :|||::              |:|.          .|:.:..|:.::..|:|.:
Human   959 SGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGK 1023

  Fly   630 -------LAVAPLSPISEKPS--------------LLDLPQEMLSRSSSTSNTRSVSAAVSNESV 673
                   |||...|..::..|              |..:|.:..|.::..:|...: |.::....
Human  1024 LKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKI-ATITTTHT 1087

  Fly   674 AGDSGVFEASRAHLPRKELAQVQIGLKYLKQE-GVLVVSLER 714
            ....|..|......|::| :|.:.......|| ....|.|||
Human  1088 PSQQGTQETRNTTKPKQE-SQFEFKAPQATQEQDFYTVELER 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	14/29 (48%)
		WW	103..132	CDD:278809	14/28 (50%)
		C2_Kibra	693..813	CDD:176062	7/23 (30%)
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492
		GuKc	122..293	CDD:214504
		WW	303..332	CDD:238122	13/28 (46%)
		WW	361..390	CDD:278809	14/28 (50%)
		PDZ	469..555	CDD:214570	14/89 (16%)
		PDZ	640..723	CDD:214570	13/97 (13%)
		MAGI_u5	722..805	CDD:293271	16/84 (19%)
		PDZ_signaling	819..894	CDD:238492	17/81 (21%)
		PDZ_signaling	968..1062	CDD:238492	15/93 (16%)
		PDZ	1123..1205	CDD:214570	4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900